Journal article
Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era
Mayo Clinic proceedings. Innovations, quality & outcomes, Vol.6(6), pp.605-617
12/2022
DOI: 10.1016/j.mayocpiqo.2022.10.001
PMCID: PMC9578336
PMID: 36277251
Abstract
To estimate rates and identify factors associated with asymptomatic COVID-19 in the population of Olmsted County during the prevaccination era.
We screened first responders (n=191) and Olmsted County employees (n=564) for antibodies to SARS-CoV-2 from November 1, 2020 to February 28, 2021 to estimate seroprevalence and asymptomatic infection. Second, we retrieved all polymerase chain reaction (PCR)-confirmed COVID-19 diagnoses in Olmsted County from March 2020 through January 2021, abstracted symptom information, estimated rates of asymptomatic infection and examined related factors.
Twenty (10.5%; 95% CI, 6.9%-15.6%) first responders and 38 (6.7%; 95% CI, 5.0%-9.1%) county employees had positive antibodies; an additional 5 (2.6%) and 10 (1.8%) had prior positive PCR tests per self-report or medical record, but no antibodies detected. Of persons with symptom information, 4 of 20 (20%; 95% CI, 3.0%-37.0%) first responders and 10 of 39 (26%; 95% CI, 12.6%-40.0%) county employees were asymptomatic. Of 6020 positive PCR tests in Olmsted County with symptom information between March 1, 2020, and January 31, 2021, 6% (n=385; 95% CI, 5.8%-7.1%) were asymptomatic. Factors associated with asymptomatic disease included age (0-18 years [odds ratio {OR}, 2.3; 95% CI, 1.7-3.1] and >65 years [OR, 1.40; 95% CI, 1.0-2.0] compared with ages 19-44 years), body mass index (overweight [OR, 0.58; 95% CI, 0.44-0.77] or obese [OR, 0.48; 95% CI, 0.57-0.62] compared with normal or underweight) and tests after November 20, 2020 ([OR, 1.35; 95% CI, 1.13-1.71] compared with prior dates).
Asymptomatic rates in Olmsted County before COVID-19 vaccine rollout ranged from 6% to 25%, and younger age, normal weight, and later tests dates were associated with asymptomatic infection.
Details
- Title: Subtitle
- Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era
- Creators
- Celine M. Vachon - Mayo ClinicAaron D. Norman - Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MNKavita Prasad - Integrative Medicine, Zumbro Valley Health Center, Mayo Clinic, Rochester, MNDan Jensen - Department of Health, Housing and Human Services Administration, Olmsted County Public Health, Mayo Clinic, Rochester, MNGavin M. Schaeferle - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MNKristy L. Vierling - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MNMeaghan Sherden - Department of Epidemiology, Surveillance and Preparedness Team, Olmsted County Public Health, Mayo Clinic, Rochester, MNMichelle R. Majerus - Administration, Hutchinson Health, Hutchinson, MNKatherine A. Bews - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MNEthan P. Heinzen - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MNAmy Hebl - Department of Human Resources, Olmsted County, Mayo Clinic, Rochester, MNKathleen J. Yost - Mayo ClinicRichard B. Kennedy - Vaccine Research Group, Division of General Internal Medicine, Mayo Clinic, Rochester, MNElitza S. Theel - Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, MNAditya Ghosh - Northeast Georgia Medical CenterMeghan Fries - University of Notre DameChung-Il Wi - Department of Precision Population Science Lab, Mayo Clinic, Rochester, MNYoung J. Juhn - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MNPriya Sampathkumar - Mayo ClinicWilliam G. Morice - Mayo ClinicWalter A. Rocca - Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MNAaron J. Tande - Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MNJames R. Cerhan - Mayo ClinicAndrew H. Limper - Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MNHenry H. Ting - Emory UniversityGianrico Farrugia - Mayo Clinic in FloridaRickey E. Carter - Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FLLila J. Finney Rutten - Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MNRobert M. Jacobson - Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MNJennifer St. Sauver - Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
- Resource Type
- Journal article
- Publication Details
- Mayo Clinic proceedings. Innovations, quality & outcomes, Vol.6(6), pp.605-617
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.mayocpiqo.2022.10.001
- PMID
- 36277251
- PMCID
- PMC9578336
- ISSN
- 2542-4548
- eISSN
- 2542-4548
- Grant note
- Mayo Clinic (https://doi.org/10.13039/100000871) COVID-19 Task Force
- Language
- English
- Date published
- 12/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368065902771
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