Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Luis Ostrosky-Zeichner; John H Rex; Michael A Pfaller; Daniel J Diekema; Barbara D Alexander; David Andes; Steven D Brown; Vishnu Chaturvedi; Mahmoud A Ghannoum; Cindy C Knapp; Daniel J Sheehan; Thomas J Walsh

doi:10.1128/AAC.00420-08

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Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Journal article

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Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Luis Ostrosky-Zeichner, John H Rex, Michael A Pfaller, Daniel J Diekema, Barbara D Alexander, David Andes, Steven D Brown, Vishnu Chaturvedi, Mahmoud A Ghannoum, Cindy C Knapp, …

Antimicrobial agents and chemotherapy, Vol.52(11), pp.4175-4177

11/2008

DOI: 10.1128/AAC.00420-08

PMCID: PMC2573146

PMID: 18809944

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Abstract

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Antifungal Agents - pharmacology

Fluconazole - pharmacology

Humans

Fluconazole - administration & dosage

Microbial Sensitivity Tests - statistics & numerical data

Candidiasis - microbiology

Candida - isolation & purification

Animals

Microbial Sensitivity Tests - standards

Time Factors

Candidiasis - drug therapy

Models, Biological

Candida - drug effects

Antifungal Agents - administration & dosage

Microbial Sensitivity Tests - methods

Databases, Factual

Details

Title: Subtitle: Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method
Creators: Luis Ostrosky-Zeichner - University of Texas Medical School at Houston, Texas 77030, USA. Luis.Ostrosky-Zeichner@uth.tmc.edu
John H Rex
Michael A Pfaller
Daniel J Diekema
Barbara D Alexander
David Andes
Steven D Brown
Vishnu Chaturvedi
Mahmoud A Ghannoum
Cindy C Knapp
Daniel J Sheehan
Thomas J Walsh
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.52(11), pp.4175-4177
DOI: 10.1128/AAC.00420-08
PMID: 18809944
PMCID: PMC2573146
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 1098-6596
eISSN: 1098-6596
Publisher: United States
Language: English
Date published: 11/2008
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986362702771

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