Journal article
Re-evaluating Blood Markers as Predictors of Outcome in Multivisceral and Intestinal Transplantation
Transplantation proceedings, Vol.53(2), pp.696-704
03/01/2021
DOI: 10.1016/j.transproceed.2021.01.004
PMID: 33558087
Abstract
Background. Multivisceral transplant (MVTx) and isolated intestinal transplant (ITx) are complex surgical procedures. The subsequent proinflammatory state in the immediate postoperative period makes interpretation of blood markers difficult.
Method. We aimed to establish the course of various blood markers after MVTx/ITx, and to evaluate their use as diagnostic markers of complications. This was a single center prospective cohort. We analyzed blood markers collected preoperatively, on alternate days for the first postoperative week, and then weekly for 4 weeks. This study was in compliance with The Declaration of Helsinki.
Results. Over a 16-month period (July 2017-October 2018), 20 subjects aged 2 to 67 years with a median age of 24.5 years received MVTx/ITx. Twelve recipients (60%) had an infection. Neutrophil lymphocyte count ratio (NLCR) was higher than established upper limits of normal, regardless of infection status. NLCR and white blood cell count were useful to identify infected MVTx/ITx recipients, with P values <.05 for 2 and 1 of 7 time points post transplant, respectively. Higher preoperative eosinophil% predicted future acute cellular rejection (P value .023).
Conclusions. This is the first study to extensively track the course of blood markers post MVTx/ITx and identified NLCR and white blood cell count as potential diagnostic blood markers of infection.
Details
- Title: Subtitle
- Re-evaluating Blood Markers as Predictors of Outcome in Multivisceral and Intestinal Transplantation
- Creators
- Donna Cheung - University of MiamiJennifer Garcia - University of MiamiThiago Beduschi - Jackson Memorial HospitalAmber Langshaw - University of MiamiKristopher Arheart - University of MiamiChris Wunsch - University of MiamiRodrigo Vianna - Jackson Memorial HospitalIvan A. Gonzalez - University of Miami
- Resource Type
- Journal article
- Publication Details
- Transplantation proceedings, Vol.53(2), pp.696-704
- Publisher
- Elsevier
- DOI
- 10.1016/j.transproceed.2021.01.004
- PMID
- 33558087
- ISSN
- 0041-1345
- eISSN
- 1873-2623
- Number of pages
- 9
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984353944802771
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