Journal article
Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4(+) and CD8(+) T effector memory cells and increase of T regulatory cells
Clinical immunology (Orlando, Fla.), Vol.207, pp.18-23
10/01/2019
DOI: 10.1016/j.clim.2019.06.010
PMCID: PMC8091796
PMID: 31255803
Abstract
BK virus (BKV), a human polyomavirus that remains latent in renal epithelial cells, can be reactivated after hematopoietic stem cell transplantation (HSCT) leading to hemorrhagic cystitis. The incidence of BK viremia is higher after Umbilical cord blood transplantation (UCBT) than HSCT from adult donors. Data regarding the role of immune recovery after UCBT in BKV reactivation is lacking. We examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of UCBT. The incidence of BK viremia was 52% and developed most frequently within the first 8 weeks after the transplantation, but persisted in seven patients at 6 months, and three patients at 1-year post UCBT. Detection of BK viremia 1 year after transplant was negatively associated with the number of CD8 cells (p = 0.03) and CD8(+)CD45RO(+) cells (p = 0.05) at 6 months, and the number of CD4(+) (p = 0.03) and CD4(+)CD45RO(+) cells (p = 0.03) at 12 months after UCBT. Conversely, BK viremia at 6 and 12 months was positively correlated with the number of T regulatory (Treg) cells at 1 month (p = 0.005 and p = 0.016, respectively). Because UCB Treg have highly potent immunosuppressive function, our findings indicate that sustained BK viremia in UCBT recipients might be associated with the increase of Treg cells early after transplantation, which mediate impaired and delayed reconstitution of CD4(+) and CD8(+) T effector cells.
Details
- Title: Subtitle
- Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4(+) and CD8(+) T effector memory cells and increase of T regulatory cells
- Creators
- Theodoros Karantanos - Beth Israel Deaconess Medical CenterHaesook T. Kim - Dana-Farber Cancer InstituteNatalia M. Tijaro-Ovalle - Beth Israel Deaconess Medical CenterLequn Li - Beth Israel Deaconess Medical CenterCorey Cutler - Dana-Farber Cancer InstituteJoseph H. Antin - Dana-Farber Cancer InstituteKaren Ballen - University of VirginiaFrancisco M. Marty - Brigham and Women's HospitalChen Sabrina Tan - Beth Israel Deaconess Medical CenterJerome Ritz - Dana-Farber Cancer InstituteIoannis Politikos - Memorial Sloan Kettering Cancer CenterVassiliki Boussiotis - Beth Israel Deaconess Medical Center
- Resource Type
- Journal article
- Publication Details
- Clinical immunology (Orlando, Fla.), Vol.207, pp.18-23
- DOI
- 10.1016/j.clim.2019.06.010
- PMID
- 31255803
- PMCID
- PMC8091796
- NLM abbreviation
- Clin Immunol
- ISSN
- 1521-6616
- eISSN
- 1521-7035
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- P01 CA142106; P30 CA008748; R01 CA183605; R21 CA123855 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984366365002771
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