Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

Scott K Powers; Erin E Talbert; Peter J Adhihetty

doi:10.1113/jphysiol.2010.201327

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Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

Journal article

Open access

Peer reviewed

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

Scott K Powers, Erin E Talbert and Peter J Adhihetty

The Journal of physiology, Vol.589(Pt 9), pp.2129-2138

05/01/2011

DOI: 10.1113/jphysiol.2010.201327

PMCID: PMC3098692

PMID: 21224240

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Abstract

It is well established that contracting skeletal muscles produce free radicals. Given that radicals are known to play a prominent role in the pathogenesis of several diseases, the 1980s-90s dogma was that contraction-induced radical production was detrimental to muscle because of oxidative damage to macromolecules within the fibre. In contrast to this early outlook, it is now clear that both reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in cell signalling pathways involved in muscle adaptation to exercise and the remodelling that occurs in skeletal muscle during periods of prolonged inactivity. This review will highlight two important redox sensitive signalling pathways that contribute to ROS and RNS-induced skeletal muscle adaptation to endurance exercise. We begin with a historical overview of radical production in skeletal muscles followed by a discussion of the intracellular sites for ROS and RNS production in muscle fibres. We will then provide a synopsis of the redox-sensitive NF-B and PGC-1α signalling pathways that contribute to skeletal muscle adaptation in response to exercise training. We will conclude with a discussion of unanswered questions in redox signalling in skeletal muscle in the hope of promoting additional research interest in this field.

Adaptation, Physiological

Animals

Heat-Shock Proteins - metabolism

Humans

Muscle Contraction

Muscle, Skeletal - metabolism

Muscle, Skeletal - pathology

NF-kappa B - metabolism

Oxidation-Reduction

Oxidative Stress

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Physical Endurance

Reactive Nitrogen Species - metabolism

Reactive Oxygen Species - metabolism

Signal Transduction

Transcription Factors - metabolism

Details

Title: Subtitle: Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle
Creators: Scott K Powers - University of Florida
Erin E Talbert - University of Florida
Peter J Adhihetty - University of Florida
Resource Type: Journal article
Publication Details: The Journal of physiology, Vol.589(Pt 9), pp.2129-2138
DOI: 10.1113/jphysiol.2010.201327
PMID: 21224240
PMCID: PMC3098692
ISSN: 0022-3751
eISSN: 1469-7793
Language: English
Date published: 05/01/2011
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
Record Identifier: 9984259639802771

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