Reactive oxygen species: influence on cerebral vascular tone

Frank M Faraci

doi:10.1152/japplphysiol.01044.2005

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Reactive oxygen species: influence on cerebral vascular tone

Journal article

Peer reviewed

Reactive oxygen species: influence on cerebral vascular tone

Frank M Faraci

Journal of applied physiology (1985), Vol.100(2), pp.739-743

02/2006

DOI: 10.1152/japplphysiol.01044.2005

PMID: 16421281

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Abstract

Reactive oxygen species have multiple effects on vascular cells. Defining the sources and the impact of the various reactive oxygen species within the vessel wall has emerged as a major area of study in vascular biology. This review will focus on recent findings related to effects of reactive oxygen species on cerebral vascular tone. Effects of superoxide radical, hydrogen peroxide, and the reactive nitrogen species peroxynitrite are summarized. Although higher concentrations may be important for cerebral vascular biology in disease, relatively low concentrations of reactive oxygen species may function as signaling molecules involved with normal regulation of cerebral vascular tone. The mechanisms by which reactive oxygen species affect vascular tone may be quite complex, and our understanding of these processes is increasing. Additionally, the role of reactive oxygen species as mediators of endothelium-dependent relaxation is addressed. Finally, the consequences of the molecular interactions of superoxide with nitric oxide and arachidonic acid are discussed.

Reactive Oxygen Species - metabolism

Cerebrovascular Circulation - physiology

Muscle, Smooth, Vascular - metabolism

Reactive Nitrogen Species - metabolism

Humans

Vasoconstriction

Male

Vasodilation

Hydrogen Peroxide - metabolism

Brain - metabolism

Isoprostanes

Brain - blood supply

Peroxynitrous Acid - metabolism

Superoxides - metabolism

Details

Title: Subtitle: Reactive oxygen species: influence on cerebral vascular tone
Creators: Frank M Faraci - Dept. of Internal Medicine, E318-2 GH, Carver College of Medicine, Univ. of Iowa, Iowa City, IA 52242, USA. frank-faraci@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.100(2), pp.739-743
Publisher: United States
DOI: 10.1152/japplphysiol.01044.2005
PMID: 16421281
ISSN: 8750-7587
eISSN: 1522-1601
Grant note: HL-38901 / NHLBI NIH HHS HL-62984 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 02/2006
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040207302771

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