Journal article
Real-World Driving Data Indexes Dopaminergic Treatment Effects in Parkinson's Disease
Movement disorders clinical practice (Hoboken, N.J.), Vol.10(9), pp.1324-1332
09/2023
DOI: 10.1002/mdc3.13803
PMCID: PMC10525064
PMID: 37772286
Abstract
Background Driving is a complex, everyday task that impacts patient agency, safety, mobility, social connections, and quality of life. Digital tools can provide comprehensive real-world (RW) data on driver behavior in patients with Parkinson's disease (PD), providing critical data on disease status and treatment efficacy in the patient's own environment. Objective This pilot study examined the use of driving data as a RW digital biomarker of PD symptom severity and dopaminergic therapy effectiveness. Methods Naturalistic driving data (3974 drives) were collected for 1 month from 30 idiopathic PD drivers treated with dopaminergic medications. Prescriptions data were used to calculate levodopa equivalent daily dose (LEDD). The association between LEDD and driver mobility (number of drives) was assessed across PD severity, measured by the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Results PD drivers with worse motor symptoms based on self-report (Part II: P = 0.02) and clinical examination (Part III: P < 0.001) showed greater decrements in driver mobility. LEDD levels >400 mg/day were associated with higher driver mobility than those with worse PD symptoms (Part I: P = 0.02, Part II: P < 0.001, Part III: P < 0.001). Conclusions Results suggest that comprehensive RW driving data on PD patients may index disease status and treatment effectiveness to improve patient symptoms, safety, mobility, and independence. Higher dopaminergic treatment may enhance safe driver mobility in PD patients with worse symptom severity.
Details
- Title: Subtitle
- Real-World Driving Data Indexes Dopaminergic Treatment Effects in Parkinson's Disease
- Creators
- Jun Ha Chang - University of Nebraska Medical CenterDanish Bhatti - University of Central FloridaMatthew Rizzo - University of Nebraska Medical CenterErgun Y. Uc - University of IowaJohn Bertoni - University of Nebraska Medical CenterJennifer Merickel - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Movement disorders clinical practice (Hoboken, N.J.), Vol.10(9), pp.1324-1332
- DOI
- 10.1002/mdc3.13803
- PMID
- 37772286
- PMCID
- PMC10525064
- NLM abbreviation
- Mov Disord Clin Pract
- ISSN
- 2330-1619
- eISSN
- 2330-1619
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- University of Nebraska Medical Center's Mind and Brain Health Labs and department of Neurological Sciences
- Language
- English
- Electronic publication date
- 06/12/2023
- Date published
- 09/2023
- Academic Unit
- Neurology
- Record Identifier
- 9984438858902771
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