Journal article
Real-World Outcomes of Endovascular Thrombectomy for Basilar Artery Occlusion: Results of the BArONIS Study
Annals of neurology, Vol.94(1), pp.55-60
07/2023
DOI: 10.1002/ana.26640
PMID: 36897101
Abstract
To evaluate clinical outcomes of endovascular thrombectomy (EVT) for acute basilar artery occlusion (BAO) using population-level data from the United States.
Weighted discharge data from the National Inpatient Sample were queried to identify adult patients with acute BAO during the period of 2015 to 2019 treated with EVT or medical management only. Complex samples statistical methods and propensity-score adjustment using inverse probability of treatment weighting (IPTW) were performed to assess clinical endpoints.
Among 3,950 BAO patients identified, 1,425 (36.1%) were treated with EVT (mean age 66.7 years, median NIHSS score 22). On unadjusted analysis, 155 (10.9%) EVT patients achieved favorable functional outcomes (discharge disposition to home without services), while 515 (36.1%) experienced in-hospital mortality, and 20 (1.4%) developed symptomatic intracranial hemorrhage (sICH). Following propensity-score adjustment by IPTW accounting for age, stroke severity, and comorbidity burden, EVT was independently associated with favorable functional outcome [adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07, 1.46; p = 0.004], but not with in-hospital mortality or sICH. In an IPTW-adjusted sub-group analysis of patients with NIHSS scores >20, EVT was associated with both favorable functional outcome (discharge disposition to home or to acute rehabilitation) (aOR 1.55, 95% CI 1.24, 1.94; p < 0.001) and decreased mortality (aOR 0.78, 95% CI 0.69, 0.89; p < 0.001), but not with sICH.
This retrospective population-based analysis using a large national registry provides real-world evidence of a potential benefit of EVT in acute BAO patients. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- Real-World Outcomes of Endovascular Thrombectomy for Basilar Artery Occlusion: Results of the BArONIS Study
- Creators
- Alis J Dicpinigaitis - School of Medicine, New York Medical College, Valhalla, New York, 10595Rosalind Dick-Godfrey - School of Medicine, New York Medical College, Valhalla, New York, 10595Olivia Gellerson - School of Medicine, New York Medical College, Valhalla, New York, 10595Steven D Shapiro - Westchester Medical CenterHaris Kamal - Westchester Medical CenterSherief A Ghozy - Departments of Neurology and Neurosurgery, Mayo Clinic, Rochester, Minnesota, 55905Gurmeen Kaur - Westchester Medical CenterShashvat M Desai - Barrow Neurological InstituteSantiago Ortega-Gutierrez - University of IowaShadi Yaghi - Brown UniversityDavid J Altschul - Montefiore Medical CenterAshutosh P Jadhav - Barrow Neurological InstituteAmeer E Hassan - The University of Texas Rio Grande ValleyThanh N Nguyen - Boston University School of MedicineAllan L Brook - Montefiore Medical CenterStephan A Mayer - Westchester Medical CenterTudor G Jovin - Cooper University HospitalRaul G Nogueira - University of Pittsburgh School of MedicineChirag D Gandhi - Westchester Medical CenterFawaz Al-Mufti - Westchester Medical Center
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.94(1), pp.55-60
- DOI
- 10.1002/ana.26640
- PMID
- 36897101
- NLM abbreviation
- Ann Neurol
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Language
- English
- Electronic publication date
- 03/10/2023
- Date published
- 07/2023
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984375350102771
Metrics
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