Realization and verification of three-dimensional conformal radiotherapy with modulated fields

Thomas Bortfeld; Arthur L Boyer; Wolfgang Schlegel; Darren L Kahler; Timothy J Waldron

doi:10.1016/0360-3016(94)90366-2

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Realization and verification of three-dimensional conformal radiotherapy with modulated fields

Journal article

Peer reviewed

Realization and verification of three-dimensional conformal radiotherapy with modulated fields

Thomas Bortfeld, Arthur L Boyer, Wolfgang Schlegel, Darren L Kahler and Timothy J Waldron

International journal of radiation oncology, biology, physics, Vol.30(4), pp.899-908

1994

DOI: 10.1016/0360-3016(94)90366-2

PMID: 7960993

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Abstract

Purpose : We describe the experimental demonstration of the delivery of a three-dimensional conformal radiotherapy dose distribution using in-field modulation of nine fixed-gantry fields. Methods and Materials : Two-dimensional in-field modulation profiles, varying from field to field, were realized by quasi-dynamic multilaf collimation using the prototype of a commercially available multileaf collimator installed on a medical linear accelerator. The profiles were calculated to deliver an optimal dose distribution for a patient with a prostate carcinoma. The target volume surface was invaginated and bifurcated. The calculated dose distribution was delivered to a homogeneous polystyrene phantom consisting of 1 cm thick slices that were cut to match the patient's outer contour. Seven therapy verification films were placed between the phantom slices. Results : Analysis of the films revealed a degree of conformation of the high-dose region to the target shape that would not be possible with unmodulated conformal therapy. However, small observed spatial displacements of the dose distribution confirm the need for very accurate positioning. Conclusions : It is feasible to deliver clinically relevant, three-dimensional dose distributions that conform to in-vaginated and bifurcated target volumes using fields modulated by multileaf collimators.

Conformal radiotherapy

Three-dimensional treatment planning

Multileaf collimators

Optimization

Inverse problem

Details

Title: Subtitle: Realization and verification of three-dimensional conformal radiotherapy with modulated fields
Creators: Thomas Bortfeld - Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Radiologie (FS 05), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Arthur L Boyer - The Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Wolfgang Schlegel - Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Radiologie (FS 05), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Darren L Kahler - The Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Timothy J Waldron - The Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Resource Type: Journal article
Publication Details: International journal of radiation oncology, biology, physics, Vol.30(4), pp.899-908
DOI: 10.1016/0360-3016(94)90366-2
PMID: 7960993
NLM abbreviation: Int J Radiat Oncol Biol Phys
ISSN: 0360-3016
eISSN: 1879-355X
Publisher: Elsevier Inc
Language: English
Date published: 1994
Academic Unit: Radiation Oncology
Record Identifier: 9984047718202771

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