Reappraisal of the provisional entity primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma: A series of 10 adult and pediatric patients and review of the literature

Christian L Baum; Brian K Link; Vishala T Neppalli; Brian L Swick; Vincent Liu

doi:10.1016/j.jaad.2010.07.028

Back

Journal article

Reappraisal of the provisional entity primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma: A series of 10 adult and pediatric patients and review of the literature

Christian L Baum, Brian K Link, Vishala T Neppalli, Brian L Swick and Vincent Liu

Journal of the American Academy of Dermatology, Vol.65(4), pp.739-748

10/2011

DOI: 10.1016/j.jaad.2010.07.028

PMID: 21641676

View Online

Abstract

Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma (PCSM-TCL) was defined as a provisional entity in the 2005 World Health Organization—European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas. A limited number of reports describe a generally indolent but heterogeneous condition. We reviewed the concept of PCSM-TCL when applied to our experience and to the published literature. We conducted a retrospective chart review and a PubMed search to identify all reported cases of PCSM-TCL from 2005 to 2010. Ten patients, including 4 of the youngest described, were identified in our institution, and their clinical and pathologic features were analyzed. All had a benign clinical course. Ten reports of patients with PCSM-TCL were reviewed and commonalities were found within an otherwise variable spectrum of clinical presentation, pathology, and biologic behavior. This study was retrospective, follow-up was short term in some cases, and data were limited in a number of published reports. Our experience of 10 cases that met the diagnostic criteria of the provisional entity PCSM-TCL highlights its occurrence in children and further supports characterization of this condition as a clonal T-cell lymphoproliferative disorder with indolent behavior.

pseudolymphoma

indolent

cutaneous T-cell lymphoma

pediatrics

peripheral T-cell lymphoma

lymphoproliferative

cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance

indolent CD8+ lymphoid proliferation

primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma

cutaneous lymphoma

Details

Title: Subtitle: Reappraisal of the provisional entity primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma: A series of 10 adult and pediatric patients and review of the literature
Creators: Christian L Baum - Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Brian K Link - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Vishala T Neppalli - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Brian L Swick - Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Vincent Liu - Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of the American Academy of Dermatology, Vol.65(4), pp.739-748
DOI: 10.1016/j.jaad.2010.07.028
PMID: 21641676
NLM abbreviation: J Am Acad Dermatol
ISSN: 0190-9622
eISSN: 1097-6787
Publisher: Elsevier Inc
Language: English
Date published: 10/2011
Academic Unit: Dermatology; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
Record Identifier: 9984025458602771

Metrics

22 Record Views

52 Times Cited - Web of Science