Journal article
Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current pharmaceutical design, Vol.21(30), pp.4479-4497
01/01/2015
DOI: 10.2174/1381612821666150817104635
PMID: 26278923
Abstract
Cardiovascular disease (CVD), accounting around 30% of deaths worldwide, collectively comprised of disorders affecting the heart and blood vessels as well as their associated adverse conditions. Despite outstanding progress in the area of the treatments of CVDs, significant challenges remain in designing of efficient delivery systems for myocardial therapy. Moreover, current therapy for CVDs is limited due to various clinical complications such as systemic toxicity, stent thrombosis, etc. Molecular and nanotechnology approaches provide the tools to explore such frontiers of biomedical science at the cellular level and thus offer unique features for potential application in the field of cardiac therapy. In this review, recent advances in CVD related risk factors, chronic inflammation, and their therapeutic modalities such as stem cell therapy, gene delivery, tissue factor (TF) inhibitors, miRNAs, leukotriene modifiers, thrombolytic agents etc., in modern molecular aspects are discussed. Moreover, nanoparticle based drug delivery, nanocarriers as molecular imaging, and the various challenges of myocardial tissue engineering aspects have been summarized. All these aspects may provide additional therapeutic substitutes in clinical trials for the registration of new drugs.
Details
- Title: Subtitle
- Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
- Creators
- Sudhanshu S. Behera - National Institute of Technology RourkelaKrishna Pramanik - National Institute of Technology RourkelaManasa K. Nayak - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current pharmaceutical design, Vol.21(30), pp.4479-4497
- Publisher
- Bentham Science Publ Ltd
- DOI
- 10.2174/1381612821666150817104635
- PMID
- 26278923
- ISSN
- 1381-6128
- eISSN
- 1873-4286
- Number of pages
- 19
- Grant note
- World Bank; The World Bank India Ministry of Human Resource Development, Government of India; Ministry of Human Resource Development (MHRD), Government of India
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359858302771
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