Journal article
Recent Advances in Zirconium-89 Chelator Development
Molecules (Basel, Switzerland), Vol.23(3), p.638
03/12/2018
DOI: 10.3390/molecules23030638
PMCID: PMC6017441
PMID: 29534538
Abstract
The interest in zirconium-89 (
Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it must be stably bound to a targeting ligand, and the most successfully used
Zr chelator is desferrioxamine B (DFO), which is commercially available as the iron chelator Desferal
. Despite the prevalence of DFO in
Zr-immuno-PET applications, the development of new ligands for this radiometal is an active area of research. This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation as DFO alternatives.
Details
- Title: Subtitle
- Recent Advances in Zirconium-89 Chelator Development
- Creators
- Nikunj B Bhatt - Wake Forest UniversityDarpan N Pandya - Wake Forest UniversityThaddeus J Wadas - Wake Forest University
- Resource Type
- Journal article
- Publication Details
- Molecules (Basel, Switzerland), Vol.23(3), p.638
- DOI
- 10.3390/molecules23030638
- PMID
- 29534538
- PMCID
- PMC6017441
- NLM abbreviation
- Molecules
- ISSN
- 1420-3049
- eISSN
- 1420-3049
- Grant note
- UL1 TR001420 / NCATS NIH HHS
- Language
- English
- Date published
- 03/12/2018
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984313081802771
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