Journal article
Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19
Frontiers in molecular biosciences, Vol.7, pp.616341-616341
12/04/2020
DOI: 10.3389/fmolb.2020.616341
PMCID: PMC7746807
PMID: 33344509
Abstract
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19). This global healthcare emergency marked the third occurrence of a deadly coronavirus (CoV) into the human society after entering the new millennium, which overwhelmed the worldwide healthcare system and affected the global economy. However, therapeutic options for COVID-19 are still very limited. Developing drugs targeting vital proteins in viral life cycle is a feasible approach to overcome this dilemma. Main protease (M
pro
) plays a dominant role in processing CoV-encoded polyproteins which mediate the assembly of replication-transcription machinery and is thus recognized as an ideal antiviral target. Here we summarize the recent progress in the discovery of anti-SARS-CoV-2 agents against M
pro
. Combining structural study, virtual screen, and experimental screen, numerous therapeutic candidates including repurposed drugs and
ab initio
designed compounds have been proposed. Such collaborative effort from the scientific community would accelerate the pace of developing efficacious treatment for COVID-19.
Details
- Title: Subtitle
- Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19
- Creators
- Wen Cui - ShanghaiTech UniversityKailin Yang - Cleveland ClinicHaitao Yang - ShanghaiTech University
- Resource Type
- Journal article
- Publication Details
- Frontiers in molecular biosciences, Vol.7, pp.616341-616341
- Publisher
- Frontiers Media S.A
- DOI
- 10.3389/fmolb.2020.616341
- PMID
- 33344509
- PMCID
- PMC7746807
- ISSN
- 2296-889X
- eISSN
- 2296-889X
- Grant note
- 2016YFD0500300 / National Key Research and Development Program of China 81772204 / National Natural Science Foundation of China 18JCJQJC48000 / Natural Science Foundation of Tianjin City
- Language
- English
- Date published
- 12/04/2020
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696581902771
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