Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry

Ranjeet Ajit Bapat; Abhishek Parolia; Tanay Chaubal; Ho Jan Yang; Prashant Kesharwani; Khoo Suan Phaik; Liang Lin Seow; Umer Daood

doi:10.3389/fmicb.2022.927282

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Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry

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Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry

Ranjeet Ajit Bapat, Abhishek Parolia, Tanay Chaubal, Ho Jan Yang, Prashant Kesharwani, Khoo Suan Phaik, Liang Lin Seow and Umer Daood

Frontiers in microbiology, Vol.13, pp.927282-927282

09/23/2022

DOI: 10.3389/fmicb.2022.927282

PMCID: PMC9539660

PMID: 36212832

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https://doi.org/10.3389/fmicb.2022.927282View

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Abstract

Quaternary ammonium silane [(QAS), codename – k21] is a novel biomaterial developed by sol-gel process having broad spectrum antimicrobial activities with low cytotoxicity. It has been used in various concentrations with maximum antimicrobial efficacy and biocompatibility. The antimicrobial mechanism is displayed via contact killing, causing conformational changes within the bacterial cell membrane, inhibiting Sortase-A enzyme, and causing cell disturbances due to osmotic changes. The compound can attach to S1' pockets on matrix metalloproteinases (MMPs), leading to massive MMP enzyme inhibition, making it one of the most potent protease inhibitors. Quaternary ammonium silane has been synthesized and used in dentistry to eliminate the biofilm from dental tissues. QAS has been tested for its antibacterial activity as a cavity disinfectant, endodontic irrigant, restorative and root canal medication, and a nanocarrier for drug delivery approaches. The review is first of its kind that aims to discuss applications of QAS as a novel antibacterial biomaterial for dental applications along with discussions on its cytotoxic effects and future prospects in dentistry.

Dentistry

Microbiology

antibacterial

antimicrobial

biomaterial

drug delivery

irrigant

quaternary ammonium silane

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Title: Subtitle: Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry
Creators: Ranjeet Ajit Bapat - IMU University
Abhishek Parolia - IMU University
Tanay Chaubal - IMU University
Ho Jan Yang - IMU University
Prashant Kesharwani - Jamia Hamdard
Khoo Suan Phaik - IMU University
Liang Lin Seow - IMU University
Umer Daood - IMU University
Resource Type: Journal article
Publication Details: Frontiers in microbiology, Vol.13, pp.927282-927282
DOI: 10.3389/fmicb.2022.927282
PMID: 36212832
PMCID: PMC9539660
NLM abbreviation: Front Microbiol
ISSN: 1664-302X
eISSN: 1664-302X
Publisher: Frontiers Media S.A
Language: English
Date published: 09/23/2022
Academic Unit: Endodontics
Record Identifier: 9984446280202771

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