Journal article
Recent advances in bioprinting using silk protein-based bioinks
Biomaterials, Vol.287, pp.121672-121672
08/2022
DOI: 10.1016/j.biomaterials.2022.121672
PMID: 35835001
Abstract
3D printing has experienced swift growth for biological applications in the field of regenerative medicine and tissue engineering. Essential features of bioprinting include determining the appropriate bioink, printing speed mechanics, and print resolution while also maintaining cytocompatibility. However, the scarcity of bioinks that provide printing and print properties and cell support remains a limitation. Silk Fibroin (SF) displays exceptional features and versatility for inks and shows the potential to print complex structures with tunable mechanical properties, degradation rates, and cytocompatibility. Here we summarize recent advances and needs with the use of SF protein from Bombyx mori silkworm as a bioink, including crosslinking methods for extrusion bioprinting using SF and the maintenance of cell viability during and post bioprinting. Additionally, we discuss how encapsulated cells within these SF-based 3D bioprinted constructs are differentiated into various lineages such as skin, cartilage, and bone to expedite tissue regeneration. We then shift the focus towards SF-based 3D printing applications, including magnetically decorated hydrogels, in situ bioprinting, and a next-generation 4D bioprinting approach. Future perspectives on improvements in printing strategies and the use of multicomponent bioinks to improve print fidelity are also discussed.
Details
- Title: Subtitle
- Recent advances in bioprinting using silk protein-based bioinks
- Creators
- Juhi Chakraborty - Indian Institute of Technology DelhiXuan Mu (Author) - University of Iowa, Roy J. Carver Department of Biomedical EngineeringAnkita Pramanick - University of IowaDavid L. Kaplan - Tufts UniversitySourabh Ghosh - Indian Institute of Technology Delhi
- Resource Type
- Journal article
- Publication Details
- Biomaterials, Vol.287, pp.121672-121672
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.biomaterials.2022.121672
- PMID
- 35835001
- ISSN
- 0142-9612
- eISSN
- 1878-5905
- Grant note
- DOI: 10.13039/501100001409, name: Department of Science and Technology, Ministry of Science and Technology, India
- Language
- English
- Date published
- 08/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984304559102771
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