Journal article
Recent advances in diagnosis and treatment of hairy cell leukemia
International journal of hematologic oncology, Vol.4(5), pp.191-200
10/2015
DOI: 10.2217/ijh.15.23
Abstract
Hairy cell leukemia (HCL) is a rare, indolent B-cell lymphoproliferative disorder that accounts for 2% of all cases of leukemia. Most patients present with pancytopenia and splenomegaly with variable number of ‘hairy’ lymphocytes in blood. BRAF V600E mutation can be detected in virtually 100% of HCL cases and is absent in other B-cell lymphomas. The mutated gene and its responding abnormal protein can be used as specific markers in the diagnosis of HCL. New therapeutic modalities targeting on mutated BRAF and its downstream pathways have shown encouraging results in clinical trials. The objective of this review article is to discuss the recent developments in the diagnosis and management of hairy cell leukemia.
Details
- Title: Subtitle
- Recent advances in diagnosis and treatment of hairy cell leukemia
- Creators
- Asad Javed - Thomas Jefferson University HospitalUpasana Joneja - Thomas Jefferson University HospitalJerald Z Gong - Thomas Jefferson University HospitalGuldeep Uppal - Thomas Jefferson University Hospital
- Resource Type
- Journal article
- Publication Details
- International journal of hematologic oncology, Vol.4(5), pp.191-200
- DOI
- 10.2217/ijh.15.23
- ISSN
- 2045-1393
- eISSN
- 2045-1407
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984362300502771
Metrics
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