Journal article
Recent advances in distal tubular potassium handling
American journal of physiology. Renal physiology, Vol.300(4), pp.F821-F827
04/01/2011
DOI: 10.1152/ajprenal.00742.2010
PMCID: PMC3074996
PMID: 21270092
Abstract
Rodan AR, Cheng C, Huang C. Recent advances in distal tubular potassium handling. Am J Physiol Renal Physiol 300: F821-F827, 2011. First published January 26, 2011; doi:10.1152/ajprenal.00742.2010.-It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium-and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium-and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.
Details
- Title: Subtitle
- Recent advances in distal tubular potassium handling
- Creators
- Aylin R. Rodan - The University of Texas Southwestern Medical CenterChih-Jen Cheng - The University of Texas Southwestern Medical CenterChou-Long Huang - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.300(4), pp.F821-F827
- DOI
- 10.1152/ajprenal.00742.2010
- PMID
- 21270092
- PMCID
- PMC3074996
- NLM abbreviation
- Am J Physiol Renal Physiol
- ISSN
- 1931-857X
- eISSN
- 1522-1466
- Publisher
- Amer Physiological Soc
- Number of pages
- 7
- Grant note
- Ministry of Defense, Taiwan DK59530; DK007275 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK059530 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 04/01/2011
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359669802771
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