Journal article
Recent advances in the synthesis of tubulysins
Mini reviews in medicinal chemistry, Vol.13(11), pp.1572-1578
10/2013
DOI: 10.2174/13895575113139990063
PMID: 23746060
Abstract
Tubulysins are a family of natural tetrapeptides in clinical development as a consequence of their potent anticancer activity, even for multi-drug resistant carcinoma. Tubulysins inhibit tubulin polymerization by binding to the peptide binding site located near the vinca alkaloid binding site of tubulin. The limited availability and pharmacological profile of the tubulysins attracted synthetic and medicinal chemists to initiate programs towards their total synthesis. This paper reviews efforts toward the total synthesis of tubulysins and selected structure-activity relationship studies of tubulysin analogs.
Details
- Title: Subtitle
- Recent advances in the synthesis of tubulysins
- Creators
- Xu Xiangming - School of Pharmacy, Yantai University, Yantai, Shandong, ChinaGregory K FriestadYao Lei
- Resource Type
- Journal article
- Publication Details
- Mini reviews in medicinal chemistry, Vol.13(11), pp.1572-1578
- Publisher
- Netherlands
- DOI
- 10.2174/13895575113139990063
- PMID
- 23746060
- ISSN
- 1389-5575
- eISSN
- 1875-5607
- Language
- English
- Date published
- 10/2013
- Academic Unit
- Chemistry
- Record Identifier
- 9983985927802771
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