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Recent advances in tuberculosis treatment: Towards shorter, safer, and more effective therapies
Journal article   Open access   Peer reviewed

Recent advances in tuberculosis treatment: Towards shorter, safer, and more effective therapies

Katherine Timboe, J.Brooks Jackson and Greta L. Becker
Journal of clinical tuberculosis and other mycobacterial diseases, Vol.42, 100582
2026
DOI: 10.1016/j.jctube.2026.100582
PMCID: PMC12854055
PMID: 41624601
url
https://doi.org/10.1016/j.jctube.2026.100582View
Published (Version of record) Open Access

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is the leading infectious cause of death globally. Although effective treatments are available, treatment length, drug toxicity, and the emergence of drug-resistant strains have challenged TB control efforts. Current clinical trials are focused on developing shorter, safer, and more effective regimens that incorporate both new and repurposed agents for the treatment of TB. This narrative review provides an overview of current and emerging treatment options for drug-susceptible, drug-resistant, and latent TB based on recent clinical trials and WHO guidelines.
Tuberculosis drug-resistant TB drug-susceptible TB Host-directed therapy latent TB Treatment regimens

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