Journal article
Recent advances in understanding the molecular basis for insulin-stimulated glucose transport
Current opinion in endocrinology & diabetes, Vol.2(4), pp.313-324
08/1995
DOI: 10.1097/00060793-199508000-00006
Abstract
The glucose transporter isoform CLUT4 is predominantly responsible for insulin-mediated glucose transport in muscle and adipose tissue. The activation of glucose transport is associated with the translocation of GLUT4-containing vesicles from an intracellular pool to the plasma membrane. Much has been learned in the past decade about the changes in the expression of this transporter in insulin-responsive tissues in diabetes mellitus and other insulin-resistant; states. The development of transgenic mice that overexpress CLUT4 or GLUT1 in muscle, adipose tissue, or both has also underscored the importance of the glucose transporters in glucose homeostasis. Data regarding which signaling steps are involved in the activation of glucose transport are just emerging, and even less is known about the molecular and cellular mechanisms governing translocation and recycling of GLUT4 vesicles. Another area of recent interest is the molecular basis of GLUT4 targeting to its intracellular vesicle.
Details
- Title: Subtitle
- Recent advances in understanding the molecular basis for insulin-stimulated glucose transport
- Creators
- E Abel - Harvard Medical School, Boston, Massachusetts, USAKaren HouseknechtBarbara Kahn
- Resource Type
- Journal article
- Publication Details
- Current opinion in endocrinology & diabetes, Vol.2(4), pp.313-324
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00060793-199508000-00006
- ISSN
- 1068-3097
- eISSN
- 1531-7064
- Language
- English
- Date published
- 08/1995
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Biochemistry and Molecular Biology; Internal Medicine; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism
- Record Identifier
- 9984025283902771
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