Journal article
Recent insights into natural product inhibitors of matrix metalloproteinases
MedChemComm, Vol.10(12), pp.2024-2037
12/12/2019
DOI: 10.1039/C9MD00165D
PMID: 32904148
Abstract
Members of the matrix metalloproteinase (MMP) family have biological functions that are central to human health and disease, and MMP inhibitors have been investigated for the treatment of cardiovascular disease, cancer and neurodegenerative disorders. The outcomes of initial clinical trials with the first generation of MMP inhibitors proved disappointing. However, our growing understanding of the complexities of the MMP function in disease, and an increased understanding of MMP protein architecture and control of activity now provide new opportunities and avenues to develop MMP-focused therapies. Natural products that affect MMP activities have been of strong interest as templates for drug discovery, and for their use as chemical tools to help delineate the roles of MMPs that still remain to be defined. Herein, we highlight the most recent discoveries of structurally diverse natural product inhibitors to these proteases.
Details
- Title: Subtitle
- Recent insights into natural product inhibitors of matrix metalloproteinases
- Creators
- Geetha B Kumar - School of Biotechnology, Amrita University, Kollam, IndiaBipin G Nair - School of Biotechnology, Amrita University, Kollam, IndiaJ. Jefferson P Perry - School of Biotechnology, Amrita University, Kollam, India, Department of BiochemistryDavid B. C Martin - Department of Chemistry, University of California, Riverside, USA, Department of Chemistry
- Resource Type
- Journal article
- Publication Details
- MedChemComm, Vol.10(12), pp.2024-2037
- DOI
- 10.1039/C9MD00165D
- PMID
- 32904148
- NLM abbreviation
- Medchemcomm
- ISSN
- 2040-2503
- eISSN
- 2040-2511
- Grant note
- DOI: 10.13039/100007602, name: University of California, Riverside; DOI: 10.13039/100014807, name: Cancer Research Coordinating Committee, award: CRN-18-526258 to DBCM, CRN-18-524906 to JJPP
- Language
- English
- Date published
- 12/12/2019
- Academic Unit
- Iowa Neuroscience Institute; Chemistry
- Record Identifier
- 9984065855902771
Metrics
7 Record Views