Journal article
Receptor Mediated Glycotargeting
Journal of drug targeting, Vol.3(2), pp.111-127
1995
DOI: 10.3109/10611869509059211
PMID: 7496725
Abstract
Abstract
Glycotargeting relies on carrier molecules possessing carbohydrates that are recognized and internalized by cell surface mammalian lectins. Numerous types of glycotargeting vehicles have been designed based on the covalent attachment of saccharides to proteins, polymers and other aglycones. These carriers have found their major applications in antiviral therapy, immunoactivation, enzyme replacement therapy and gene therapy. This review compares different types of glycotargeting agents and the lectins which have been successfully targeted to treat both model and human diseases. It may be concluded that the discovery of new mammalian lectins which endocytose their ligands will lead to the rapid development of new glycotargeting agents founded on the principles of carbohydrate-protein interactions.
Details
- Title: Subtitle
- Receptor Mediated Glycotargeting
- Creators
- Manpreet S Wadhwa - College of Pharmacy, Ohio State University, Columbus, OH, 43210Kevin G Rice - College of Pharmacy, Ohio State University, Columbus, OH, 43210
- Resource Type
- Journal article
- Publication Details
- Journal of drug targeting, Vol.3(2), pp.111-127
- DOI
- 10.3109/10611869509059211
- PMID
- 7496725
- NLM abbreviation
- J Drug Target
- ISSN
- 1061-186X
- eISSN
- 1029-2330
- Publisher
- Informa UK Ltd
- Language
- English
- Date published
- 1995
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065316402771
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