Journal article
Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival
Trends in parasitology, Vol.28(8), pp.335-344
08/2012
DOI: 10.1016/j.pt.2012.05.002
PMCID: PMC3399048
PMID: 22726697
Abstract
The extracellular promastigote stage of Leishmania spp. is transmitted to mammals by a sand fly vector. Leishmania promastigotes ligate host macrophage receptors, triggering phagocytosis and subsequent internalization, a crucial step for survival. Parasites transform intracellularly to the amastigote stage. Many studies document different receptors detecting promastigotes and amastigotes, but the relative importance of each interaction is ill-defined. Recent studies suggest that the macrophage receptors utilized during phagocytosis impact the intracellular fate of the parasite. This review summarizes the receptors implicated in Leishmania phagocytosis over the past 30 years. It then proceeds to weigh the evidence for or against their potential roles in intracellular parasite trafficking.
Details
- Title: Subtitle
- Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival
- Creators
- Norikiyo Ueno - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USAMary E Wilson - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Trends in parasitology, Vol.28(8), pp.335-344
- DOI
- 10.1016/j.pt.2012.05.002
- PMID
- 22726697
- PMCID
- PMC3399048
- NLM abbreviation
- Trends Parasitol
- ISSN
- 1471-4922
- eISSN
- 1471-5007
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001148502771
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