Journal article
Recipes for creating animal models of diabetic cardiovascular disease
Circulation research, Vol.100(10), pp.1415-1427
2007
DOI: 10.1161/01.RES.0000266449.37396.1f
PMID: 17525381
Abstract
For more than 50 years, investigators have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of diabetes seen in humans. In particular, accelerated atherosclerosis and dilated cardiomyopathy, the major causes of mortality in patients with diabetes, have been conspicuously absent in many mouse models of the disease. Under the auspices of the NIH, the Animal Models of Diabetic Complications Consortium has worked to address this issue. This effort has focused on the development of mouse models because of the high level of genomic information available and the many well-developed genetic manipulations that may be performed in mice. Importantly, the consortium has also worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications. Finally, for maximum benefits from these animal models in the study of atherosclerosis and of other diabetic complications, the consortium has created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community.
Details
- Title: Subtitle
- Recipes for creating animal models of diabetic cardiovascular disease
- Creators
- Willa HSUEH - Division of Endocrinology, Diabetes, and Hypertension, The David Geffen School of Medicine, University of California, Los Angeles, United StatesE. Dale ABEL - Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, United StatesCristina RABADAN-DIEHL - Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Md., United StatesIra J GOLDBERG - Department of Medicine, Columbia University, New York, United StatesJan L BRESLOW - Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, United StatesNobuyo MAEDA - Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United StatesRichard C DAVIS - Department of Medicine, Division of Cardiology, The David Geffen School of Medicine, University of California, Los Angeles, United StatesEdward A FISHER - Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, The Leon H. Charney Division of CardiologyNew York University School of Medicine, United StatesHayes DANSKY - Department of Medicine, Columbia University, New York, United StatesDonald A MCCLAIN - Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, United StatesRichard MCLNDOE - Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, United StatesMomtaz K WASSEF - Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Md., United States
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.100(10), pp.1415-1427
- Publisher
- Lippincott; Hagerstown, MD
- DOI
- 10.1161/01.RES.0000266449.37396.1f
- PMID
- 17525381
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024566302771
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