Journal article
Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice
Arteriosclerosis, thrombosis, and vascular biology, Vol.32(2), pp.230-235
2012
DOI: 10.1161/ATVBAHA.111.241406
PMCID: PMC3281771
PMID: 22173228
Abstract
Objective—Gpihbp1-deficient (Gpihbp1−/−) mice lack the ability to transport lipoprotein lipase to the capillary lumen, resulting in mislocalization of lipoprotein lipase within tissues, defective lipolysis of triglyceride-rich lipoproteins, and chylomicronemia. We asked whether GPIHBP1 deficiency and mislocalization of catalytically active lipoprotein lipase would alter the composition of triglycerides in adipose tissue or perturb the expression of lipid biosynthetic genes. We also asked whether perturbations in adipose tissue composition and gene expression, if they occur, would be accompanied by reciprocal metabolic changes in the liver. Methods and Results—The chylomicronemia in Gpihbp1−/− mice was associated with reduced levels of essential fatty acids in adipose tissue triglycerides and increased expression of lipid biosynthetic genes. The liver exhibited the opposite changes: increased levels of essential fatty acids in triglycerides and reduced expression of lipid biosynthetic genes. Conclusion—Defective lipolysis in Gpihbp1−/− mice causes reciprocal metabolic perturbations in adipose tissue and liver. In adipose tissue, the essential fatty acid content of triglycerides is reduced and lipid biosynthetic gene expression is increased, whereas the opposite changes occur in the liver.
Details
- Title: Subtitle
- Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice
- Creators
- Michael M WEINSTEIN - Departments of Medicine, University of California, Los Angeles, CA, United StatesChristopher N GOULBOURNE - Departments of Medicine, University of California, Los Angeles, CA, United StatesLoren G FONG - Departments of Medicine, University of California, Los Angeles, CA, United StatesStephen G YOUNG - Departments of Medicine, University of California, Los Angeles, CA, United StatesBrandon S. J DAVIES - Departments of Medicine, University of California, Los Angeles, CA, United StatesYiping Tu - Departments of Medicine, University of California, Los Angeles, CA, United StatesRichard H Barnes II - Departments of Medicine, University of California, Los Angeles, CA, United StatesSteven M WATKINS - Tethys Bioscience, Emeryville, CA, United StatesRyan DAVIS - Tethys Bioscience, Emeryville, CA, United StatesKaren REUE - Human Genetics, University of California, Los Angeles, CA, United StatesPeter TONTONOZ - Pathology, University of California, Los Angeles, CA, United StatesAnne P BEIGNEUX - Departments of Medicine, University of California, Los Angeles, CA, United States
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.32(2), pp.230-235
- Publisher
- Lippincott Williams & Wilkins; Philadelphia, PA
- DOI
- 10.1161/ATVBAHA.111.241406
- PMID
- 22173228
- PMCID
- PMC3281771
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Language
- English
- Date published
- 2012
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9984024419302771
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