Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

Arpana Agrawal; Rebecca Tillman; Richard A Grucza; Elliot C Nelson; Vivia V McCutcheon; Lauren Few; Kenneth R Conner; Michael T Lynskey; Danielle M Dick; Howard J Edenberg; Victor M Hesselbrock; John R Kramer; Samuel Kuperman; John I Nurnberger; Marc A Schuckit; Bernice Porjesz; Kathleen K Bucholz

doi:10.1016/j.jad.2016.12.060

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Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

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Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

Arpana Agrawal, Rebecca Tillman, Richard A Grucza, Elliot C Nelson, Vivia V McCutcheon, Lauren Few, Kenneth R Conner, Michael T Lynskey, Danielle M Dick, Howard J Edenberg, …

Journal of affective disorders, Vol.213, pp.96-104

04/15/2017

DOI: 10.1016/j.jad.2016.12.060

PMCID: PMC5434702

PMID: 28213124

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https://soar.suny.edu/bitstream/20.500.12648/8073/1/nihms852774.pdfView

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Abstract

Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. Ideation was related to 0.71–0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44–1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. Suicide attempts are associated with increased likelihood of onset of substance dependence. •Suicide attempts are associated with the onset of substance dependence.•Associations persist even after accounting for key covariates.•Prior suicidal ideation reduces the likelihood of onset of substance use.•Limited evidence that early substance use is associated with onset of suicidality.

Ideation

Cannabis

Attempt

Alcohol

COGA

Suicide

Nicotine

Details

Title: Subtitle: Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism
Creators: Arpana Agrawal - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Rebecca Tillman - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Richard A Grucza - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Elliot C Nelson - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Vivia V McCutcheon - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Lauren Few - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Kenneth R Conner - University of Rochester Medical Center, Dept. of Emergency Medicine, Rochester, NY, USA
Michael T Lynskey - Kings College, Institute of Psychiatry, Dept. of Addiction, London, UK
Danielle M Dick - Virginia Commonwealth University, Dept. of African-American Studies, Richmond, VA, USA
Howard J Edenberg - Indiana University, Dept. of Biochemistry and Molecular Biology, Indianapolis, IN, USA
Victor M Hesselbrock - University of Connecticut Health, Dept. of Psychiatry, Farmington, CT, USA
John R Kramer - University of Iowa Carver College of Medicine, Dept. of Psychiatry – Div. of Psychology, Iowa City, IA, USA
Samuel Kuperman - University of Iowa Carver College of Medicine, Depts. of Psychiatry and Pediatrics, Iowa City, IA, USA
John I Nurnberger - Indiana University School of Medicine, Dept. of Psychiatry, Indianapolis, IN, USA
Marc A Schuckit - University of California San Diego, Dept. of Psychiatry, San Diego, CA, USA
Bernice Porjesz - SUNY Downstate Medical Center, Dept. of Psychiatry, Brooklyn, NY, USA
Kathleen K Bucholz - Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.213, pp.96-104
DOI: 10.1016/j.jad.2016.12.060
PMID: 28213124
PMCID: PMC5434702
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: DA040411; DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: K02DA032573; DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism (NIAAA), award: U10AA008401
Language: English
Date published: 04/15/2017
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003404002771

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