Journal article
Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts
Journal of allergy and clinical immunology, Vol.133(4), pp.961-966
04/2014
DOI: 10.1016/j.jaci.2013.11.043
PMCID: PMC4009347
PMID: 24582311
Abstract
The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to routine immunizations has prompted the Medical Advisory Committee of the Immune Deficiency Foundation to issue recommendations based on published literature and the collective experience of the committee members. These recommendations address the concern for immunodeficient patients acquiring infections from healthy subjects who have not been immunized or who are shedding live vaccine–derived viral or bacterial organisms. Such transmission of infectious agents can occur within the hospital, clinic, or home or at any public gathering. Collectively, we define this type of transmission as close-contact spread of infectious disease that is particularly relevant in patients with impaired immunity who might have an infection when exposed to subjects carrying vaccine-preventable infectious diseases or who have recently received a live vaccine. Immunodeficient patients who have received therapeutic hematopoietic stem transplantation are also at risk during the time when immune reconstitution is incomplete or while they are receiving immunosuppressive agents to prevent or treat graft-versus-host disease. This review recommends the general education of what is known about vaccine-preventable or vaccine-derived diseases being spread to immunodeficient patients at risk for close-contact spread of infection and describes the relative risks for a child with severe immunodeficiency. The review also recommends a balance between the need to protect vulnerable subjects and their social needs to integrate into society, attend school, and benefit from peer education.
Details
- Title: Subtitle
- Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts
- Creators
- William T Shearer - Baylor College of Medicine and Texas Children's Hospital, Houston, TexThomas A Fleisher - National Institutes of Health Clinical Center, Bethesda, MdRebecca H Buckley - Duke University School of Medicine, Durham, NCZuhair Ballas - University of Iowa and Iowa City Veterans Affairs Medical Center, Iowa City, IowaMark Ballow - State University of New York, Children's Hospital of Buffalo, Buffalo, NYR. Michael Blaese - Immune Deficiency Foundation, Columbia, MdFrancisco A Bonilla - Boston Children's Hospital, Boston, MassMary Ellen Conley - University of Tennessee Health Science Center and St Jude Children's Research Center, Memphis, TennCharlotte Cunningham-Rundles - Mt Sinai Medical Center, New York, NYAlexandra H Filipovich - Cincinnati Children's Hospital, Cincinnati, OhioRamsay Fuleihan - Ann & Robert H. Lurie Children's Hospital of ChicagoErwin W Gelfand - National Jewish Health, Denver, ColoVivian Hernandez-Trujillo - Miami Children's Hospital, Miami, FlaSteven M Holland - National Institute of Allergy and Infectious Diseases, Bethesda, MdRichard Hong - Private practice, Shelburne, VtHoward M Lederman - Johns Hopkins University School of Medicine, Baltimore, MdHarry L Malech - National Institute of Allergy and Infectious Diseases, Bethesda, MdStephen Miles - All Seasons Allergy, Asthma & Immunology, Shenandoah, TexLuigi D Notarangelo - Boston Children's Hospital, Boston, MassHans D Ochs - Seattle Children's Hospital, Seattle, WashJordan S Orange - Baylor College of Medicine and Texas Children's Hospital, Houston, TexJennifer M Puck - University of California San Francisco, San Francisco, CalifJohn M Routes - Children's Hospital of Wisconsin, Milwaukee, WisE. Richard Stiehm - UCLA School of Medicine, Los Angeles, CalifKathleen Sullivan - Children's Hospital of Philadelphia, Philadelphia, PaTroy Torgerson - Seattle Children's Hospital, Seattle, WashJerry Winkelstein - Johns Hopkins University School of Medicine, Baltimore, MdMedical Advisory Committee of the Immune Deficiency Foundation
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.133(4), pp.961-966
- DOI
- 10.1016/j.jaci.2013.11.043
- PMID
- 24582311
- PMCID
- PMC4009347
- NLM abbreviation
- J Allergy Clin Immunol
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Publisher
- Elsevier Inc
- Grant note
- Department of Health and Human Services NIH National Institute of Allergy and Infectious Diseases National Institutes of Health CSL Behring Intramural Research Program of the National Institutes of Health Clinical Center Baxter Biosciences
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094310902771
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