Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis

Marisol Betensky; Ketan Kulkarni; Mattia Rizzi; Sophie Jones; Leonardo R. Brandão; Edward Vincent S. Faustino; Neil A. Goldenberg; Anjali Sharathkumar

doi:10.1111/jth.15731

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Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis

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Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis

Marisol Betensky, Ketan Kulkarni, Mattia Rizzi, Sophie Jones, Leonardo R. Brandão, Edward Vincent S. Faustino, Neil A. Goldenberg and Anjali Sharathkumar

Journal of thrombosis and haemostasis, Vol.20(7), pp.1729-1734

07/2022

DOI: 10.1111/jth.15731

PMCID: PMC9324216

PMID: 35570328

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Abstract

Clinically unsuspected venous thromboembolism (VTE) in children is defined as a VTE diagnosed via imaging test performed for surveillance (i.e., with an intent to identify clinically silent VTEs) or incidentally found (most often via imaging performed for evaluation of regional pathology unrelated to VTE) in the absence of any VTE‐associated signs or symptoms. Our understanding of the clinical significance of these events in children is limited by a paucity of data on the epidemiology and outcomes of this complication. There is an urgent need for further research in this area to inform optimal management. Recognizing this knowledge gap, this Task Force has previously published a systematic review of the literature in this topic. We now provide guidance recommendations for standardization of definitions and identify future research needs on clinically unsuspected VTE in children. These recommendations will serve to enhance the quantity and quality of evidence on the topic and facilitate the design and execution of cooperative observational studies, and interventional trials of risk‐stratified management approaches aimed at preventing and optimizing long‐term outcomes of clinically unsuspected VTE in children.

asymptomatic venous thromboembolism

pediatric

unsuspected venous thromboembolism

Details

Title: Subtitle: Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
Creators: Marisol Betensky - Johns Hopkins Medicine
Ketan Kulkarni - Izaak Walton Killam Health Centre
Mattia Rizzi - University Hospital of Lausanne
Sophie Jones - Royal Children's Hospital
Leonardo R. Brandão - Hospital for Sick Children
Edward Vincent S. Faustino - Yale University
Neil A. Goldenberg - Johns Hopkins Medicine
Anjali Sharathkumar - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Journal of thrombosis and haemostasis, Vol.20(7), pp.1729-1734
DOI: 10.1111/jth.15731
PMID: 35570328
PMCID: PMC9324216
NLM abbreviation: J Thromb Haemost
ISSN: 1538-7933
eISSN: 1538-7836
Number of pages: 6
Language: English
Date published: 07/2022
Academic Unit: Stead Family Department of Pediatrics; Hematology/Oncology
Record Identifier: 9984354003002771

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