Journal article
Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis
Immunological reviews, Vol.297(1), pp.53-66
09/01/2020
DOI: 10.1111/imr.12886
PMCID: PMC7643606
PMID: 32564424
Abstract
Leishmaniasis is a global health problem that affects more than 2 billion people worldwide. Recent advances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes duringLeishmaniaspp. infection and pathogenesis. Specifically, several studies have focused on the role of nod-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome and inflammasome-associated cytokines IL-1 beta and IL-18 in leishmaniasis. Despite these studies, our understanding of the priming and activation events that lead to NLRP3 inflammasome activation duringLeishmaniaspp. infection is limited. Furthermore, whether NLRP3 plays a protective or pathogenic role duringLeishmaniaspp. infection is far from resolved, with some studies showing a protective role and others showing a pathogenic role. In this review, we performed a critical review of the literature to provide a current update on priming and activating signals required for NLRP3 inflammasome activation duringLeishmaniaspp. infection. Finally, we provide a thorough review of the literature to reconcile differences in the observed protective vs pathogenic roles of the NLRP3 inflammasome duringLeishmaniaspp. infection.
Details
- Title: Subtitle
- Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis
- Creators
- Valerie Harrington - University of IowaPrajwal Gurung - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.297(1), pp.53-66
- DOI
- 10.1111/imr.12886
- PMID
- 32564424
- PMCID
- PMC7643606
- NLM abbreviation
- Immunol Rev
- ISSN
- 0105-2896
- eISSN
- 1600-065X
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- R21 AI148904 01 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) University of Iowa R25GM116686 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 09/01/2020
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984359886202771
Metrics
8 Record Views