Journal article
Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future
Genes, brain and behavior, Vol.21(5), e12803
03/14/2022
DOI: 10.1111/gbb.12803
PMCID: PMC9189007
PMID: 35285132
Abstract
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence-based interventions for core symptoms. With no established biological markers, diagnoses are defined by behavioral criteria. Thus, preclinical in vivo animal models of NDDs must be optimally utilized. For this reason, experts in the field of behavioral neuroscience convened a workshop with the goals of reviewing current behavioral studies, reports, and assessments in rodent models. Goals included: (a) identifying the maximal utility and limitations of behavior in animal models with construct validity; (b) providing recommendations for phenotyping animal models; and (c) guidelines on how in vivo models should be used and reported reliably and rigorously while acknowledging their limitations. We concluded by recommending minimal criteria for reporting in manuscripts going forward. The workshop elucidated a consensus of potential solutions to several problems, including revisiting claims made about animal model links to ASD (and related conditions). Specific conclusions included: mice (or other rodent or preclinical models) are models of the neurodevelopmental insult, not specifically any disorder (e.g., ASD); a model that perfectly recapitulates a disorder such as ASD is untenable; and greater attention needs be given to validation of behavioral testing methods, data analysis, and critical interpretation.
Details
- Title: Subtitle
- Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future
- Creators
- Jill L Silverman - University of California, DavisAudrey Thurm - National Institute of Mental HealthSarah B Ethridge - National Institute of Mental HealthMakayla M Soller - University of California, DavisStela P Petkova - University of California, DavisTed Abel - University of IowaMelissa D Bauman - University of California, DavisEdward S Brodkin - University of PennsylvaniaHala Harony-Nicolas - Icahn School of Medicine at Mount SinaiMarkus Wöhr - Philipps University of MarburgAlycia Halladay - Rutgers, The State University of New Jersey
- Resource Type
- Journal article
- Publication Details
- Genes, brain and behavior, Vol.21(5), e12803
- DOI
- 10.1111/gbb.12803
- PMID
- 35285132
- PMCID
- PMC9189007
- NLM abbreviation
- Genes Brain Behav
- eISSN
- 1601-183X
- Grant note
- R01NS097808 / NINDS NIH HHS P50 HD103526 / NICHD NIH HHS P50 HD 103556 / University of Iowa Hawkeye Intellectual and Developmental Disorders Research Center National Institute of Child Health and Human Development Autism Science Foundation 1ZICMH002961 / National Institute of Mental Health Intramural Research Program WO 1732/4-2 / DFG NIH/NICHD P50 HD105354 / CHOP/Penn Intellectual and Developmental Disabilities Research Center
- Language
- English
- Date published
- 03/14/2022
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984229358702771
Metrics
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