Journal article
Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase
Biochemical and biophysical research communications, Vol.96(2), pp.882-889
1980
DOI: 10.1016/0006-291X(80)91438-2
PMID: 6775632
Abstract
The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED
50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED
50 ∼12 μmol·kg
−1) was approximately seven times less than the ED
50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.
Details
- Title: Subtitle
- Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase
- Creators
- Andrew Parkinson - University of GuelphLarry W. Robertson - University of GuelphStephen Safe - University of Guelph
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.96(2), pp.882-889
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0006-291X(80)91438-2
- PMID
- 6775632
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 1980
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984363606802771
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