Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease

Hirokazu Uchigami; Masashi Hamada; Hirotaka Maekawa; Hiroyuki Ishiura; Satoshi Kodama; Yuichiro Shirota; Miwako Takahashi; Toshimitsu Momose; Tatsushi Toda

doi:10.2169/internalmedicine.1015-22

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Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease

Journal article

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Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease

Hirokazu Uchigami, Masashi Hamada, Hirotaka Maekawa, Hiroyuki Ishiura, Satoshi Kodama, Yuichiro Shirota, Miwako Takahashi, Toshimitsu Momose and Tatsushi Toda

Internal medicine (Tokyo, 1992), Vol.63(2), pp.333-336

01/15/2024

DOI: 10.2169/internalmedicine.1015-22

PMID: 37258170

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Abstract

Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of consciousness preceded by an acute-onset headache. During that time, we performed N-isopropyl-p-[ I] iodoamphetamine single-photon-emission computed tomography twice and found that the blood flow increased in different regions. Prolonged disturbance of consciousness following an encephalitic episode may be associated with repeated hyperperfusion in various regions resulting from mitochondrial dysfunction. NIID patients presenting with encephalitic episodes can recover gradually and spontaneously even after prolonged disturbances of consciousness.

Cerebrovascular Circulation

Consciousness

Dementia - complications

Encephalitis - complications

Humans

Intranuclear Inclusion Bodies

Neurodegenerative Diseases - complications

Neurodegenerative Diseases - diagnostic imaging

Details

Title: Subtitle: Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease
Creators: Hirokazu Uchigami - The University of Tokyo
Masashi Hamada - The University of Tokyo
Hirotaka Maekawa - The University of Tokyo
Hiroyuki Ishiura - The University of Tokyo
Satoshi Kodama - The University of Tokyo
Yuichiro Shirota - University of Tokyo Hospital
Miwako Takahashi - National Institutes for Quantum Science and Technology
Toshimitsu Momose - International University of Health and Welfare
Tatsushi Toda - The University of Tokyo
Resource Type: Journal article
Publication Details: Internal medicine (Tokyo, 1992), Vol.63(2), pp.333-336
DOI: 10.2169/internalmedicine.1015-22
PMID: 37258170
ISSN: 0918-2918
eISSN: 1349-7235
Language: English
Date published: 01/15/2024
Academic Unit: Neurology
Record Identifier: 9985177940002771

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