Journal article
Recovery of Human immunodeficiency Virus from Ocular Tissues in Patients with Acquired Immune Deficiency Syndrome
Ophthalmology (Rochester, Minn.), Vol.95(10), pp.1458-1462
10/1988
DOI: 10.1016/S0161-6420(88)33011-3
PMID: 2852338
Abstract
Human immunodeficiency virus (HIV) was recovered from multiple ocular tissues in three patients with acquired immune deficiency syndrome (AIDS). Consistently found in the retina, HIV was also detected in the conjunctiva, cornea, and iris. In two cases, HIV was detectable despite treatment with oral zidovudine. All three patients had bilateral cytomegalovirus (CMV) retinitis managed by intravitreal injection of ganciclovir. Culture of the retina for CMV was negative in all three cases. The finding of HIV in multiple ocular tissues is consistent with the neurotropic nature of the virus, and may explain some of the common ocular manifestations of AIDS such as AIDS retinopathy. Infection with HIV may predispose the retina to other opportunistic infections and may explain the high incidence of CMV retinitis in AIDS patients. This is the first report of HIV isolation from tissue within the eye.
Details
- Title: Subtitle
- Recovery of Human immunodeficiency Virus from Ocular Tissues in Patients with Acquired Immune Deficiency Syndrome
- Creators
- Herbert L Cantrill - Department of Ophthalmology, University of Minnesota School of Medicine, MinneapolisKeith Henry - Department of Internal Medicine, St. Paul Ramsey Medical Center, St. PaulBrooks Jackson - Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, MinneapolisAlejo Erice - Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, MinneapolisFred M Ussery - Department of Ophthalmology, Baylor University, HoustonHenry H Balfour - Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.95(10), pp.1458-1462
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0161-6420(88)33011-3
- PMID
- 2852338
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Language
- English
- Date published
- 10/1988
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047984602771
Metrics
22 Record Views