Journal article
Recruitment of HIV and its receptors to dendritic cell-T cell junctions
Science (American Association for the Advancement of Science), Vol.300(5623), pp.1295-1297
05/23/2003
DOI: 10.1126/science.1084238
PMID: 12730499
Abstract
Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigen-specific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.
Details
- Title: Subtitle
- Recruitment of HIV and its receptors to dendritic cell-T cell junctions
- Creators
- David McDonald - Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USALi WuStacy M BohksVineet N KewalRamaniDerya UnutmazThomas J Hope
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.300(5623), pp.1295-1297
- DOI
- 10.1126/science.1084238
- PMID
- 12730499
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- United States
- Grant note
- R01-AI49131 / NIAID NIH HHS R01 AI052051 / NIAID NIH HHS R01-AI52051 / NIAID NIH HHS R01-AI47770 / NIAID NIH HHS
- Language
- English
- Date published
- 05/23/2003
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002387302771
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