Journal article
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
Nature communications, Vol.4(1), pp.1795-1795
04/01/2013
DOI: 10.1038/ncomms2766
PMCID: PMC3649763
PMID: 23653207
Abstract
Tumours recruit mesenchymal stem cells to facilitate healing, which induces their conversion into cancer-associated fibroblasts that facilitate metastasis. However, this process is poorly understood on the molecular level. Here we show that CXCL16, a ligand for CXCR6, facilitates mesenchymal stem cell or very small embryonic-like cells recruitment into prostate tumours. CXCR6 signalling stimulates the conversion of mesenchymal stem cells into cancer-associated fibroblasts, which secrete stromal-derived factor-1, also known as CXCL12. CXCL12 expressed by cancer-associated fibroblasts then binds to CXCR4 on tumour cells and induces an epithelial-to-mesenchymal transition, which ultimately promotes metastasis to secondary tumour sites. Our results provide the molecular basis for mesenchymal stem cell recruitment into tumours and how this process leads to tumour metastasis.
Details
- Title: Subtitle
- Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
- Creators
- Younghun Jung - University of MichiganJin Koo Kim - University of MichiganYusuke Shiozawa - University of MichiganJingcheng Wang - University of MichiganAnjali Mishra - University of MichiganJeena Joseph - University of MichiganJanice E. Berry - University of MichiganSamantha McGee - University of MichiganEunsohl Lee - University of MichiganHongli Sun - University of MichiganJianhua Wang - Shanghai Jiao Tong UniversityTaocong Jin - University of MichiganHonglai Zhang - University of MichiganJinlu Dai - University of MichiganPaul H. Krebsbach - University of MichiganEvan T. Keller - University of MichiganKenneth J. Pienta - University of MichiganRussell S. Taichman - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.4(1), pp.1795-1795
- DOI
- 10.1038/ncomms2766
- PMID
- 23653207
- PMCID
- PMC3649763
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- Department of Defense; United States Department of Defense CA163124; CA093900; CA166307; CA069568; DK082481; MH095589 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 81071747 / National Natural Funding of China 10PJ1406400 / Shanghai Pujiang Program Prostate Cancer Foundation R03MH095589 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P50CA069568 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 2011CB510106 / National Key Program (973) for Basic Research of China; National Basic Research Program of China Fund for Cancer Research R01DK082481 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 04/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367748602771
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