Journal article
Recurrent Atypical Hemolytic Uremic Syndrome in Children With Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy
Journal of pediatric hematology/oncology, Vol.40(7), pp.560-562
10/2018
DOI: 10.1097/MPH.0000000000000987
PMID: 28991131
Abstract
Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.
Details
- Title: Subtitle
- Recurrent Atypical Hemolytic Uremic Syndrome in Children With Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy
- Creators
- Geoffrey Cheng - Division of Hematology/OncologyBulent Ozgonenel - Division of Hematology/OncologyKanta Bhambhani - Division of Hematology/OncologyGaurav Kapur - Division of NephrologyRichard J Smith - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IASüreyya Savaşan - Carmen Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric hematology/oncology, Vol.40(7), pp.560-562
- DOI
- 10.1097/MPH.0000000000000987
- PMID
- 28991131
- NLM abbreviation
- J Pediatr Hematol Oncol
- ISSN
- 1077-4114
- eISSN
- 1536-3678
- Publisher
- United States
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006357702771
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