Journal article
Recurrent Cardiovascular Events with Paclitaxel-Eluting Versus Bare-Metal Stents in Saphenous Vein Graft Lesions: Insights from the SOS (Stenting of Saphenous Vein Grafts) Trial
The Journal of invasive cardiology, Vol.23(6), pp.216-219
06/01/2011
PMID: 21646644
Abstract
The Stenting of Saphenous Vein Grafts (SOS) trial demonstrated a reduction in clinical and angiographic adverse events with paclitaxel-eluting stents (PES) compared to bare-metal stents (BMS) in saphcnous vein graft (SVG) lesions, but the rate of recurrent adverse events has not been described. Methods. We performed a post hoc, landmark analysis to evaluate the risk of event recurrence following a non-fatal initial event among the SOS trial patients (pts). Results. During a median follow-up of 35 months, the 80 pts enrolled in SOS experienced a total of 78 major cardiovascular events (MACE): 51 in the BMS group and 27 in PES group. No MACE were found in 28 pts (35%) while 52 pis (65%) had at least one event. The initial event was death in 13 pts (16%). Among the 39 pts whose initial event was not fatal, 12 (31%) had one or more subsequent MACE (50% of which were definitely related to the study SVG). The mean and median number of MACE per patient was significantly higher in patients receiving BMS versus PES (1.3 +/- 1.2 and 1 +/- 1.26 versus 0.6 +/- 0.7 and 1 +/- 0.825,p = 0.005 and p = 0.008, respectively). The rate of a second MACE following an initial event was 17% in the PES group and 37% in the BMS group (p = 0.24). Ten of 12 pts with recurrent events had received a BMS (83%). Conclusion. Pts undergoing SVG stenting had a high rate of recurrent events after an initial non-fatal event. These events were often related to the target vessel and most occurred in pts who had received a BMS, further supporting the benefit of PES over BMS in SVG lesions.
Details
- Title: Subtitle
- Recurrent Cardiovascular Events with Paclitaxel-Eluting Versus Bare-Metal Stents in Saphenous Vein Graft Lesions: Insights from the SOS (Stenting of Saphenous Vein Grafts) Trial
- Creators
- Tesfaldet T. Michael - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAAbdul-rahman R. Abdel-karim - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAAristotelis Papayannis - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAChristopher Lichtenwalter - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAJames A. de Lemos - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAOwen Obel - Vet Affairs N Texas Healthcare Syst, Dallas, TX USATayo Addo - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAMichele Roesle - Vet Affairs N Texas Healthcare Syst, Dallas, TX USADonald Haagen - Vet Affairs N Texas Healthcare Syst, Dallas, TX USABavana V. Rangan - Vet Affairs N Texas Healthcare Syst, Dallas, TX USABilal Saeed - Univ Toledo, Dept Internal Med, Toledo, OH 43606 USAJoseph K. Bissett - Univ Arkansas Med Sci, Little Rock, AR 72205 USARajesh Sachdeva - Univ Arkansas Med Sci, Little Rock, AR 72205 USAVassilios V. Voudris - Onassis Cardiac Surg Ctr, Athens, GreecePanagiotis Karyofillis - Onassis Cardiac Surg Ctr, Athens, GreeceBiswajit Kar - Michael E DeBakey VA Med Ctr, Houston, TX USAJames Rossen - Iowa City Vet Affairs Med Ctr, Iowa City, IA USAPanayotis Fasseas - Med Coll Wisconsin, Milwaukee, WI 53226 USAPeter B. Berger - Weis Ctr Res, Geisinger Clin, Danville, PA 17822 USASubhash Banerjee - Vet Affairs N Texas Healthcare Syst, Dallas, TX USAEmmanouil S. Brilakis - Vet Affairs N Texas Healthcare Syst, Dallas, TX USA
- Resource Type
- Journal article
- Publication Details
- The Journal of invasive cardiology, Vol.23(6), pp.216-219
- Publisher
- H M P Communications
- PMID
- 21646644
- ISSN
- 1042-3931
- eISSN
- 1557-2501
- Number of pages
- 4
- Grant note
- Harris Methodist Foundation Abbott Vascular and Infraredx Boston Scientific Johnson and Johnson; Johnson & Johnson; Johnson & Johnson USA VISN-17 / Department of Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984302203702771
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