Journal article
Recurrent Severe Hypoinsulinemic Hypoglycemia Responsive to Temozolomide and Bevacizumab in a Patient With Doege-Potter Syndrome
The American journal of the medical sciences, Vol.356(2), pp.181-184
08/2018
DOI: 10.1016/j.amjms.2018.01.008
PMID: 30219161
Abstract
Nonislet cell tumor hypoglycemia is rare. We highlight the diagnosis and treatment of recurrent severe hypoglycemia in a 49-year-old woman with malignant solitary fibrous tumor of the pleura (Doege-Potter syndrome). The clinical, laboratory and radiologic findings of the case are presented and a brief literature review is provided. Of note, imaging studies showed a large mass in the right hemithorax and pathology and immunehistochemical stains confirmed a malignant solitary fibrous tumor of the pleura. She was a poor surgical candidate owing to a large tumor burden. She was treated with a combination of temozolomide and bevacizumab to which she responded with resolution of hypoglycemia. The treatment of choice for hypoglycemia in patients with the Doege-Potter syndrome is surgical excision. We here report that a combination of temozolomide and bevacizumab may be a viable option in patients with inoperable disease.
Details
- Title: Subtitle
- Recurrent Severe Hypoinsulinemic Hypoglycemia Responsive to Temozolomide and Bevacizumab in a Patient With Doege-Potter Syndrome
- Creators
- Amie A Ogunsakin - University of Tennessee Health Science CenterHolly L Hilsenbeck - Memphis Pathology Group, Memphis, Tennessee.David C Portnoy - West Cancer CenterEbenezer A Nyenwe - University of Tennessee Health Science Center
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.356(2), pp.181-184
- DOI
- 10.1016/j.amjms.2018.01.008
- PMID
- 30219161
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359777202771
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