Journal article
Recurrent intracerebral hemorrhage in patients with cerebral amyloid angiopathy: a propensity-matched case–control study
Journal of neurology, Vol.269(4), pp.2200-2205
01/17/2022
DOI: 10.1007/s00415-021-10937-4
PMID: 35037138
Abstract
Objective
Cerebral amyloid angiopathy (CAA) can present with intracerebral hemorrhage (ICH), convexity subarachnoid hemorrhage (SAH), and rarely acute ischemic stroke (AIS). The objective of our study was to compare the readmission rates for recurrent ICH, SAH, and AIS among patients admitted for ICH with and without CAA.
Methods
Using the National Readmissions Database 2016–2018 we identified patients admitted for ICH with and without a concomitant diagnosis of CAA. Primary outcome of the study was readmission due to ICH. Secondary outcomes included readmissions due to AIS and SAH. Survival analysis was performed, and Kaplan–Meier curves were created to assess for readmissions.
Results
The study consisted of 194,290 patients with ICH, 8247 with CAA and 186,043 without CAA as a concomitant diagnosis. After propensity matching, we identified 7857 hospitalizations with CAA and 7874 without CAA. Patients with CAA had higher risk of readmission due to ICH as compared to those without CAA [hazards ratio (HR) 3.44, 95% confidence interval (CI) 2.55–4.64,
P
< 0.001] during the mean follow-up period of 181.4 (SD ± 106.4) days. Patients with CAA were also more likely to be readmitted due to SAH (HR 2.52, 95% CI 1.18–5.37,
P
0.017) but not due to AIS (HR 0.74, 95% CI 0.54–1.01,
P
0.061). Age (HR 0.96 per year increase in age, 95% CI 0.94–0.98,
P
< 0.001) and Medicare payer (HR 3.31; 95% CI 1.89–5.78,
P
< 0.001) were independently associated with readmissions due to ICH.
Discussion
Patients admitted for ICH with a concomitant diagnosis of CAA are three times more likely to have readmissions for recurrent ICH compared to patients without CAA.
Details
- Title: Subtitle
- Recurrent intracerebral hemorrhage in patients with cerebral amyloid angiopathy: a propensity-matched case–control study
- Creators
- Aayushi Garg - University of IowaSantiago Ortega‑Gutierrez - University of Iowa Hospitals and ClinicsMudassir Farooqui - University of IowaNandakumar Nagaraja - Penn State Milton S. Hershey Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, Vol.269(4), pp.2200-2205
- DOI
- 10.1007/s00415-021-10937-4
- PMID
- 35037138
- NLM abbreviation
- J Neurol
- ISSN
- 0340-5354
- eISSN
- 1432-1459
- Publisher
- Springer Berlin Heidelberg
- Language
- English
- Date published
- 01/17/2022
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984302199602771
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