Journal article
Recurrent or persistent salivary gland enlargement in children: When is it Sjögren's?
Seminars in arthritis and rheumatism, Vol.52, pp.151945-151945
02/2022
DOI: 10.1016/j.semarthrit.2021.11.011
PMID: 35000785
Abstract
To describe characteristic features in children with recurrent or persistent salivary gland enlargement and to propose a diagnostic algorithm with specific consideration for Sjögren's disease (SD).
In this single-center, prospective study, 45 patients < 18 years, with recurrent or persistent salivary gland enlargement of unknown etiology were enrolled from 2006 to 2019. We collected detailed clinical information to characterize this group of patients including specific details of their major salivary gland signs and symptoms. We compared clinical, laboratory and radiological parameters between 4 groups based on the results of labial salivary gland biopsy (LSGB) and between patients who met existing SD criteria or not.
44 patients, with a mean age of 6.8 years and female to male ratio 21:23 were observed over a mean of 3.8 years. Characteristics of salivary gland swelling episodes varied considerably between individuals, but the majority experienced ≤5 episodes per year, lasting ≤ 1 week, with swelling affecting either or both glands. Ocular and oral dryness symptoms were observed only in 25% and 59% patients, respectively. The majority were positive for ANA, but negative for SD-specific antibodies. A total of 75% patients fulfilled at least one of the existing SD criteria.
SD is a major cause of recurrent salivary gland enlargement in children. For children meeting adult criteria, the diagnosis of SD is clear. However, for the many children without dryness symptoms, objective dryness, or SD-specific antibodies, further workup including a combination of salivary gland imaging and histopathological examination can help establish the diagnosis of SD.
Details
- Title: Subtitle
- Recurrent or persistent salivary gland enlargement in children: When is it Sjögren's?
- Creators
- Anna Pomorska - Gdańsk Medical UniversityDominik Świętoń - University of GdańskScott M. Lieberman - University of IowaEwa Bryl - Gdańsk Medical UniversityWojciech Kosiak - Gdańsk Medical UniversityRafał Pęksa - Gdańsk Medical UniversityJuliusz Chorążewicz - Gdańsk Medical UniversityBarbara Kochańska - Gdańsk Medical UniversityJustyna Kowalska-Skabara - Gdańsk Medical UniversityMałgorzata Szumera - Gdańsk Medical UniversityWojciech Brzoznowski - Gdańsk Medical UniversityRadosław Jaworski - Children's Memorial Health InstituteNinela Irga-Jaworska - Gdańsk Medical University
- Resource Type
- Journal article
- Publication Details
- Seminars in arthritis and rheumatism, Vol.52, pp.151945-151945
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.semarthrit.2021.11.011
- PMID
- 35000785
- ISSN
- 0049-0172
- eISSN
- 1532-866X
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984354043302771
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