Journal article
Recurrent paralogy in the evolution of archaeal chaperonins
Current biology, Vol.9(18), pp.1053,S1-1056,S6
09/23/1999
DOI: 10.1016/S0960-9822(99)80457-6
PMID: 10508614
Abstract
Chaperonins are multisubunit double-ring complexes that mediate the folding of nascent proteins [1,2]. In bacteria, chaperonins are homo-oligomeric and are composed of seven-membered rings. Eukaryotic and most archaeal chaperonin rings are eight-membered and exhibit varying degrees of hetero-oligomerism [3,4]. We have cloned and sequenced seven new genes encoding chaperonin subunits from the crenarchaeotes Sulfolobus solfataricus, S. acidocaldarius, S. shibatae and Desulfurococcus mobilis. Although some archaeal genomes possess a single chaperonin gene, most have two. We describe a third chaperonin-encoding gene (TF55-γ) from two Sulfolobus species; phylogenetic analyses indicate that the gene duplication producing TF55-γ occurred within crenarchaeal evolution. The presence of TF55-γ in Sulfolobus correlates with their unique nine-membered chaperonin rings. Duplicate genes (paralogs) for chaperonins within archaeal genomes very often resemble each other more than they resemble chaperonin genes from other archaea. Our phylogenetic analyses suggest multiple independent gene duplications – at least seven among the archaea examined. The persistence of paralogous genes for chaperonin subunits in multiple archaeal lineages may involve a process of co-evolution, where chaperonin subunit heterogeneity changes independently of selection on function.
Details
- Title: Subtitle
- Recurrent paralogy in the evolution of archaeal chaperonins
- Creators
- John M Archibald - Department of Biochemistry and Molecular Biology, Program in Evolutionary Biology, Canadian Institute for Advanced Research, Dalhousie University, Halifax, Nova Scotia B3H 4H7, CanadaJohn M Logsdon - Department of Biochemistry and Molecular Biology, Program in Evolutionary Biology, Canadian Institute for Advanced Research, Dalhousie University, Halifax, Nova Scotia B3H 4H7, CanadaW.Ford Doolittle - Department of Biochemistry and Molecular Biology, Program in Evolutionary Biology, Canadian Institute for Advanced Research, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
- Resource Type
- Journal article
- Publication Details
- Current biology, Vol.9(18), pp.1053,S1-1056,S6
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0960-9822(99)80457-6
- PMID
- 10508614
- ISSN
- 0960-9822
- eISSN
- 1879-0445
- Language
- English
- Date published
- 09/23/1999
- Academic Unit
- Biology
- Record Identifier
- 9984217538602771
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