Recurrent respiratory papillomatosis: pathogenesis to treatment

John H Lee; Richard J Smith

doi:10.1097/01.moo.0000186205.91332.46

Back

Journal article

Recurrent respiratory papillomatosis: pathogenesis to treatment

John H Lee and Richard J Smith

Current opinion in otolaryngology & head and neck surgery, Vol.13(6), pp.354-359

12/2005

DOI: 10.1097/01.moo.0000186205.91332.46

PMID: 16282764

View Online

Abstract

Recurrent respiratory papillomatosis remains a serious disease and is commonly treated by otolaryngologists. The goals of this review are to update physicians on current understandings regarding viral pathogenesis, patient risks, and current trends in treatment strategies. Surgical debulking still remains the foundation of treatment; however, newer surgical approaches utilizing microdebriders are replacing laser ablation. Genetic studies have identified individuals with specific immune cell alleles to be at greater risk for persistent infection. Our understanding of the viral pathogenesis has increased by the identification of a viral mechanism to downregulate antigen expression in cells infected with human papillomavirus, thus possibly allowing decreased immune detection. Although the viral types responsible for recurrent respiratory papillomatosis have been identified, the mechanism by which they alter cellular growth has not been identified. Research studies investigating adjuvant medical therapies aimed at reducing required surgical therapy intervals and possibly helping cure the infection are being completed. A safe, effective adjuvant therapy is still currently not available. Improved surgical approaches have slightly enhanced patient care; however, more research is needed to understand how human papillomavirus causes disease so that these therapies can be developed.

Cytosine - analogs & derivatives

Laryngeal Neoplasms - surgery

Human papillomavirus 6 - immunology

Organophosphonates - therapeutic use

Humans

Laser Therapy

Neoplasm Recurrence, Local - therapy

Papillomavirus Infections - surgery

Interferon-alpha - therapeutic use

Neoplasm Recurrence, Local - drug therapy

Antineoplastic Agents - therapeutic use

Neoplasm Recurrence, Local - surgery

Papillomavirus Infections - therapy

Laryngeal Neoplasms - therapy

Viral Vaccines

Papilloma - surgery

Laryngeal Neoplasms - drug therapy

Papillomavirus Infections - drug therapy

Indoles - therapeutic use

Cytosine - therapeutic use

Chemotherapy, Adjuvant

Human papillomavirus 11 - immunology

Papilloma - therapy

Papilloma - drug therapy

Details

Title: Subtitle: Recurrent respiratory papillomatosis: pathogenesis to treatment
Creators: John H Lee - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. john-h-lee@uiowa.edu
Richard J Smith
Resource Type: Journal article
Publication Details: Current opinion in otolaryngology & head and neck surgery, Vol.13(6), pp.354-359
DOI: 10.1097/01.moo.0000186205.91332.46
PMID: 16282764
NLM abbreviation: Curr Opin Otolaryngol Head Neck Surg
ISSN: 1068-9508
eISSN: 1531-6998
Publisher: United States
Language: English
Date published: 12/2005
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
Record Identifier: 9984006431602771

Metrics

26 Record Views

See more details