Journal article
Recurrent systemic bacterial infections in homozygous C2 deficiency
Pediatric allergy and immunology, Vol.1(1), pp.46-49
Received 1 February 1990 Accepted 25 April 1990
10/1990
DOI: 10.1111/j.1399-3038.1990.tb00008.x
Abstract
Homozygous deficiency of the second component of complement (C2) occurs in one in 10, 000 individuals. Its clinical manifestations range from essentially no symptoms to recurrent infections or evidence of collagen‐vascular disease. We present here a case report and a review of the literature focusing on recurrent systemic infections in C2‐deficient individuals. Thirteen of 20 patients vi'ith C2 deficiency and a history of invasive bacterial infections have had recurrent episodes of bacteremia or meningitis. Most of these patients were children, and Streptococcus pneumoniae was the most common pathogen reported. The use of prophylactic antibiotics. Haemophilus influenzae type b and pneumococcal vaccines, and prompt medical attention for any febrile illness should be encouraged in children with documented C2 deficiency. Although there are no studies to date to document their efficacy, the above measures may serve to diminish the frequency of recurrent systemic bacterial disease in these children. Copyright © 1990, Wiley Blackwell. All rights reserved
Details
- Title: Subtitle
- Recurrent systemic bacterial infections in homozygous C2 deficiency
- Creators
- M. B Fasano - The Eudowood Division of Immunology, The Department of Pediatrics, The Johns Hopkins University School of Medicine Baltimore, Maryland U. S. AA Hamosh - The Eudowood Division of Immunology, The Department of Pediatrics, The Johns Hopkins University School of Medicine Baltimore, Maryland U. S. AJ. A Winkelstein - The Eudowood Division of Immunology, The Department of Pediatrics, The Johns Hopkins University School of Medicine Baltimore, Maryland U. S. A
- Resource Type
- Journal article
- Publication Details
- Pediatric allergy and immunology, Vol.1(1), pp.46-49
- Edition
- Received 1 February 1990 Accepted 25 April 1990
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1399-3038.1990.tb00008.x
- ISSN
- 0905-6157
- eISSN
- 1399-3038
- Number of pages
- 4
- Language
- English
- Date published
- 10/1990
- Academic Unit
- Immunology; Internal Medicine; Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984093478102771
Metrics
23 Record Views