Recurrently situational (reactive) depression: A study of course, phenomenology and familial psychopathology

William Coryell; George Winokur; Jack D Maser; Hagop S Akiskal; Martin B Keller; Jean Endicott

doi:10.1016/0165-0327(94)90030-2

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Recurrently situational (reactive) depression: A study of course, phenomenology and familial psychopathology

Journal article

Open access

Peer reviewed

Recurrently situational (reactive) depression: A study of course, phenomenology and familial psychopathology

William Coryell, George Winokur, Jack D Maser, Hagop S Akiskal, Martin B Keller and Jean Endicott

Journal of affective disorders, Vol.31(3), pp.203-210

1994

DOI: 10.1016/0165-0327(94)90030-2

PMID: 7963073

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Abstract

Probands with non-bipolar major depressive disorder (MDD) were grouped according to the consistency across episodes with which depression appeared to arise from situational factors. Situational depression showed significant diagnostic stability across the second and third recurrences in a 10-year follow-up. The relatives of recurrently situational probands had higher neuroticism scores, higher lifetime rates of MDD and, when depressed, fewer endogenous symptoms than did the relatives of non-situational probands. This study joins two others in finding an association between stress-related depression and high familial loadings for MDD. It also illustrates the value of diagnostic consistency across episodes as a means of refining groups for the study of diagnostic subtypes.

Situational

Major depression

Familial

Follow-up

Details

Title: Subtitle: Recurrently situational (reactive) depression: A study of course, phenomenology and familial psychopathology
Creators: William Coryell - Psychiatry Administration, University of Iowa College of Medicine, 200 Hawkins Drive 2887 JPP, Iowa City, IA, USA
George Winokur - Psychiatry Administration, University of Iowa College of Medicine, 200 Hawkins Drive 2887 JPP, Iowa City, IA, USA
Jack D Maser - National Institute of Mental Health, Rockville, MD, USA
Hagop S Akiskal - National Institute of Mental Health, Rockville, MD, USA
Martin B Keller - Brown University Department of Psychiatry, Providence, RI, USA
Jean Endicott - New York State Psychiatric Institute, New York, NY, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.31(3), pp.203-210
DOI: 10.1016/0165-0327(94)90030-2
PMID: 7963073
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 1994
Academic Unit: Psychiatry
Record Identifier: 9984003484802771

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