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Red Blood Cells Store and Release Interleukin-33
Journal article   Peer reviewed

Red Blood Cells Store and Release Interleukin-33

Jianxin Wei, Jing Zhao, Valerie Schrott, Yingze Zhang, Mark Gladwin, Grant Bullock and Yutong Zhao
Journal of investigative medicine, Vol.63(6), pp.806-810
08/01/2015
DOI: 10.1097/JIM.0000000000000213
PMCID: PMC4767276
PMID: 26107423
url
https://www.ncbi.nlm.nih.gov/pmc/articles/4767276View
Open Access

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives production of a variety of cytokines and contributes to the pathogenesis of inflammatory diseases. The IL-33 is a nuclear protein and is released from apoptotic or necrotic cells. Serum IL-33 levels are increased in various diseases, such as atopic dermatitis, chronic hepatitis C infection, and asthma. Here, we show that red blood cells (RBCs) are one of the major sources of plasma IL-33. The IL-33 levels are significantly increased in supernatants from lysed RBCs. Plasma IL-33 levels are increased in patients during hemolysis, and plasma IL-33 levels show a positive correlation with degree of hemolysis. The IL-33 protein and messenger RNA levels were detected in the late stages of differentiation in ex vivo primary human erythroid progenitor cell cultures, suggesting that IL-33 is expressed during maturation of RBCs. Furthermore, hemoglobin depleted red cell lysates induced IL-8 expression in human epithelial cells. This effect was attenuated in IL-33 decoy receptor expressing cells and was enhanced in IL-33 receptor expressing cells. These results suggest that erythroid progenitor cells produce IL-33 and circulating RBCs represent a major source of IL-33 that is released upon hemolysis.

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