Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

Alexander Bautista; Theodore B Wright; Janice Meany; Sunitha K Kandadai; Benjamin Brown; Kareim Khalafalla; Saeed Hashem; Jason W Smith; Tayyeb M Ayyoubi; Jarrod E Dalton; Anupama Wadhwa; Daniel I Sessler; Detlef Obal

doi:10.1155/2017/3718615

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Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

Journal article

Open access

Peer reviewed

Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

Alexander Bautista, Theodore B Wright, Janice Meany, Sunitha K Kandadai, Benjamin Brown, Kareim Khalafalla, Saeed Hashem, Jason W Smith, Tayyeb M Ayyoubi, Jarrod E Dalton, …

BioMed research international, Vol.2017, pp.3718615-12

01/01/2017

DOI: 10.1155/2017/3718615

PMCID: PMC5446873

PMID: 28589139

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Abstract

Prolonged storage of packed red blood cells (PRBCs) may increase morbidity and mortality, and patients having massive transfusion might be especially susceptible. We therefore tested the hypothesis that prolonged storage increases mortality in patients receiving massive transfusion after trauma or nontrauma surgery. Secondarily, we considered the extent to which storage effects differ for trauma and nontrauma surgery. We considered surgical patients given more than 10 units of PRBC within 24 hours and evaluated the relationship between mean PRBC storage duration and in-hospital mortality using multivariable logistic regression. Potential nonlinearities in the relationship were assessed via restricted cubic splines. The secondary hypothesis was evaluated by considering whether there was an interaction between the type of surgery (trauma versus nontrauma) and the effect of storage duration on outcomes. 305 patients were given a total of 8,046 units of PRBCs, with duration ranging from 8 to 36 days (mean ± SD: 22 ± 6 days). The odds ratio [95% confidence interval (CI)] for in-hospital mortality corresponding to a one-day in mean PRBC storage duration was 0.99 (0.95, 1.03, = 0.77). The relationship did not differ for trauma and nontrauma patients ( = 0.75). Results were similar after adjusting for multiple potential confounders. Mortality after massive blood transfusion was no worse in patients transfused with PRBC stored for long periods. Trauma and nontrauma patients did not differ in their susceptibility to prolonged PRBC storage.

Adult

Aged

Blood Preservation

Databases, Factual

Erythrocyte Transfusion

Erythrocytes

Female

Hospital Mortality

Humans

Male

Middle Aged

Retrospective Studies

Time Factors

Wounds and Injuries - mortality

Wounds and Injuries - surgery

Details

Title: Subtitle: Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients
Creators: Alexander Bautista - University of Louisville
Theodore B Wright - University of Louisville
Janice Meany - University of Louisville Hospital
Sunitha K Kandadai - University of Louisville
Benjamin Brown - University of Louisville
Kareim Khalafalla - University of Louisville
Saeed Hashem - University of Louisville
Jason W Smith - University of Louisville
Tayyeb M Ayyoubi - University of Louisville Hospital
Jarrod E Dalton - Cleveland Clinic
Anupama Wadhwa - University of Louisville
Daniel I Sessler - Cleveland Clinic
Detlef Obal - University of Louisville
Resource Type: Journal article
Publication Details: BioMed research international, Vol.2017, pp.3718615-12
DOI: 10.1155/2017/3718615
PMID: 28589139
PMCID: PMC5446873
NLM abbreviation: Biomed Res Int
ISSN: 2314-6133
eISSN: 2314-6141
Language: English
Date published: 01/01/2017
Academic Unit: Anesthesia
Record Identifier: 9984696570502771

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