Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999-2004

Sandip K ZALAWADIYA; Vikas VEERANNA; Sidakpal S PANAICH; Luis AFONSO

doi:10.1177/1358863X12442443

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Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999-2004

Journal article

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Peer reviewed

Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999-2004

Sandip K ZALAWADIYA, Vikas VEERANNA, Sidakpal S PANAICH and Luis AFONSO

Vascular medicine (London, England), Vol.17(3), pp.155-163

2012

DOI: 10.1177/1358863X12442443

PMID: 22615191

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Abstract

Red cell distribution width (RDW) is an independent predictor of the 10-year estimated risk of coronary heart disease (CHD) events. However, RDW's association with peripheral artery disease (PAD) - a CHD risk equivalent - has not been evaluated to date. In this cross-sectional study, we examined 6950 participants of the National Health and Nutrition Examination Survey, 1999-2004. PAD was defined as an ankle-brachial index below 0.9 (n = 618). RDW was divided into quartiles (Q) (Q1: ≤ 12.2; Q2: 12.3-12.5; Q3: 12.6-13.0; Q4: ≥ 13.1) and PAD risk was compared across these quartiles using adjusted multivariate logistic regression. A graded increase in prevalent PAD with increasing RDW quartiles was observed (4.2% in Q1 vs 13.9% in Q4; test of trend p < 0.001). Risk of PAD was significantly higher (odds ratio (OR) 1.19, 95% confidence interval (CI): 1.06-1.34; p = 0.003) after adjusting for age, sex, race, body mass index, hypertension, hyperlipidemia, diabetes, smoking, estimated glomerular filtration rate, C-reactive protein, hemoglobin, mean corpuscular volume, and nutritional factors (folate, iron and vitamin B(12)) deficiencies with each unit (0.1) increase in RDW. Upon receiver-operating characteristics analysis, the predictive accuracy of the American College of Cardiology / American Heart Association (ACC/AHA)-defined PAD screening criteria (for a high-risk population) was 0.657 at best, but improved significantly (0.727) after addition of RDW (p < 0.0001). In conclusion, higher levels of RDW are independently associated with a higher risk of PAD and can significantly improve the risk prediction beyond that estimated by ACC/AHA-defined PAD screening criteria.

Fundamental and applied biological sciences. Psychology

Cardiology. Vascular system

Blood vessels and receptors

Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous

Biological and medical sciences

Medical sciences

Vertebrates: cardiovascular system

Blood and lymphatic vessels

Details

Title: Subtitle: Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999-2004
Creators: Sandip K ZALAWADIYA - Division of Cardiology, Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, MI, United States
Vikas VEERANNA - Division of Cardiology, Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, MI, United States
Sidakpal S PANAICH - Division of Cardiology, Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, MI, United States
Luis AFONSO - Division of Cardiology, Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, MI, United States
Resource Type: Journal article
Publication Details: Vascular medicine (London, England), Vol.17(3), pp.155-163
DOI: 10.1177/1358863X12442443
PMID: 22615191
NLM abbreviation: Vasc Med
ISSN: 1358-863X
eISSN: 1477-0377
Publisher: Arnold
Language: English
Date published: 2012
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094532202771

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