Journal article
Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin
Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.45(1), pp.7-10
07/1978
DOI: 10.1152/jappl.1978.45.1.7
PMID: 27486
Abstract
Studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (DPG), the intracellular red cell and extracellular pH, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. Adult hemoglobin first appeared near 120 days of gestation. The mean oxygen tension at which hemoglobin is half saturated (P50) prior to 120 days of gestation remained constant at 13.9 +/- 0.3 (SD) Torr and then increased gradually as gestation continued, reaching 19 Torr at term. During the interval of fetal life studied, the level of DPG was 4.43 +/- 1.63 (SD) micromol/g Hb and the deltapH between plasma and red blood cells was 0.227 +/- 0.038 (SD); neither was affected by gestational age. The decrease in the red cell oxygen affinity after 120 days of gestation ocrrelated with the amount of adult hemoglobin present in the fetus (r = 0.78; P less than 0.001). This decrease can be attributed only to the amount of the adult-type hemoglobin present, and not to DPG, or to changes in the deltapH between plasma and red blood cells, because both remained stable during the last trimester.
Details
- Title: Subtitle
- Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin
- Creators
- H BardJ C FouronJ E RobillardA CornetM A Soukini
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.45(1), pp.7-10
- Publisher
- United States
- DOI
- 10.1152/jappl.1978.45.1.7
- PMID
- 27486
- ISSN
- 0161-7567
- eISSN
- 2691-2465
- Language
- English
- Date published
- 07/1978
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984025331302771
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