Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting

Hao Hong; Fei Wang; Yin Zhang; Stephen A Graves; Savo Bou Zein Eddine; Yunan Yang; Charles P Theuer; Robert J Nickles; Xudong Wang; Weibo Cai

doi:10.1021/am508440j

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Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting

Journal article

Peer reviewed

Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting

Hao Hong, Fei Wang, Yin Zhang, Stephen A Graves, Savo Bou Zein Eddine, Yunan Yang, Charles P Theuer, Robert J Nickles, Xudong Wang and Weibo Cai

ACS applied materials & interfaces, Vol.7(5), pp.3373-3381

02/11/2015

DOI: 10.1021/am508440j

PMCID: PMC4326560

PMID: 25607242

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url

https://www.osti.gov/servlets/purl/1345171View

Open Access

Abstract

Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. Here we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2=12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.

Animals

Antibodies, Monoclonal - pharmacokinetics

Breast Neoplasms - diagnostic imaging

Breast Neoplasms - metabolism

Breast Neoplasms - pathology

Cell Line, Tumor

Copper Radioisotopes - pharmacokinetics

Female

Fluorescent Dyes - chemistry

Metal Nanoparticles - chemistry

Metal Nanoparticles - ultrastructure

Mice

Mice, Inbred BALB C

Microscopy, Fluorescence - methods

Multimodal Imaging - methods

Nanocapsules - chemistry

Nanocapsules - ultrastructure

Positron-Emission Tomography - methods

Radiopharmaceuticals - pharmacokinetics

Zinc Oxide

Details

Title: Subtitle: Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting
Creators: Hao Hong - University of Wisconsin–Madison
Fei Wang - University of Wisconsin–Madison
Yin Zhang - University of Wisconsin–Madison
Stephen A Graves
Savo Bou Zein Eddine - University of Wisconsin–Madison
Yunan Yang - University of Wisconsin–Madison
Charles P Theuer - Tracon Pharmaceuticals (United States)
Robert J Nickles - University of Wisconsin–Madison
Xudong Wang - University of Wisconsin–Madison
Weibo Cai - University of Wisconsin Carbone Cancer Center
Resource Type: Journal article
Publication Details: ACS applied materials & interfaces, Vol.7(5), pp.3373-3381
DOI: 10.1021/am508440j
PMID: 25607242
PMCID: PMC4326560
NLM abbreviation: ACS Appl Mater Interfaces
ISSN: 1944-8244
eISSN: 1944-8252
Grant note: T32 CA009206 / NCI NIH HHS R01 CA169365 / NCI NIH HHS P30CA014520 / NCI NIH HHS P30 CA014520 / NCI NIH HHS 1R01CA169365 / NCI NIH HHS
Language: English
Date published: 02/11/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383307702771

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