Journal article
Redistribution of inhaled hyperpolarized He-3 gas during breath-hold differs by asthma severity
Journal of applied physiology (1985), Vol.120(5), pp.526-536
03/01/2016
DOI: 10.1152/japplphysiol.00197.2015
PMCID: PMC4773646
PMID: 26635346
Abstract
The purpose of this work was to quantify the redistribution of ventilation-weighted signal in the lungs of asthmatic subjects during a breath-hold using high temporal-spatial resolution hyperpolarized (HP) He-3 MRI. HP He-3 MRI was used to obtain time-resolved, volumetric images of lung ventilation during breath-hold in 39 human subjects classified as either healthy/nondiseased (n = 14), mild-tomoderate asthmatic (n = 17), or severely asthmatic (n = 8). Signals were normalized to a standard lung volume, so that voxels within the lung from all 39 subjects could be analyzed as a group to increase statistical power and enable semiautomated classification of voxels into 1 of 5 ventilation level categories (ranging from defect to hyperintense). End-inspiratory ventilation distribution and temporal rates of mean signal change for each of the five ventilation categories were compared using ANOVA. Time rates of signal change were hypothesized to represent underlying gas redistribution processes, potentially influenced by disease. We found that mild-to-moderate asthmatic subjects showed the greatest rate of signal change, even though those with severe asthma had the greatest end-inspiration ventilation heterogeneity. The observed results support the existence of local differences in airway resistances associated with the different obstructive patterns in the lungs for severe vs. mild-to-moderate asthmatic subjects.
Details
- Title: Subtitle
- Redistribution of inhaled hyperpolarized He-3 gas during breath-hold differs by asthma severity
- Creators
- Andrew D. Hahn - University of Wisconsin–MadisonRobert V. Cadman - University of Wisconsin–MadisonRonald L. Sorkness - University of Wisconsin–MadisonNizar N. Jarjour - University of Wisconsin–MadisonScott K. Nagle - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.120(5), pp.526-536
- DOI
- 10.1152/japplphysiol.00197.2015
- PMID
- 26635346
- PMCID
- PMC4773646
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- Amer Physiological Soc
- Number of pages
- 11
- Grant note
- 5 T32 CA009206 / NIH/National Cancer Institute Radiological Sciences Training Grant UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Department of Radiology, School of Medicine and Public Health, University of Wisconsin (UW)-Madison T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Department of Medical Physics, School of Medicine and Public Health, UW-Madison UL1TR000427; KL2TR000428 / NIH Grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NIH-NHLBI R01-HL-080412; NIH-NHLBI R01-HL-069116; NIH-NHLBI U10-HL-109168 / National Institutes of Health-(NIH) National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Hartwell Foundation U10HL109168 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 03/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274954702771
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